桂枝芍药知母汤联合甲氨蝶呤治疗类风湿关节炎寒湿痹阻证的效果

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Abstract Objective To investigate the effect of Guizhi Shaoyao Zhimu Decoction combined with Methotrexate in the treatment of cold-damp blockage syndrome of rheumatoid arthritis. Methods Eighty cases of cold-damp blockage syndrome of rheumatoid arthritis patients admitted to Lu’an People’s Hospital of Anhui Province from February 2017 to May 2020 were selected and they were divided into control group and study group according to random number table method, with 40 cases in each group. The control group was treated with Methotrexate, and the study group was treated with Guizhi Shaoyao Zhimu Decoction on the basis of the control group. After two months of treatment, the clinical efficacy and the incidence of adverse reactions of the two groups were compared, and the levels of inflammatory factors and the recovery of joint function were analyzed before and after two months of treatment. Results After two months of treatment, the total effective rate of the study group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). After two months of treatment, the levels of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in both groups were decreased compared with before treatment, and those in the study group were lower than those in the control group, with statistical significance (P ＜ 0.05). After two months of treatment, the morning stiffness time, joint pain index, joint swelling number and joint tenderness number in both groups were lower than before treatment, and the study group was lower than the control group, the differences were statistically significant (P ＜ 0.05). The total incidence of adverse reactions in the study group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Guizhi Shaoyao Zhimu Decoction combined with Methotrexate has a significant effect on cold-damp blockage syndrome of rheumatoid arthritis patients, and can significantly reduce the levels of CRP, TNF-α and IL-6, which is worthy of promotion and application.

Key words： Rheumatoid arthritis Cold-damp blockage syndrome Guizhi Shaoyao Zhimu Decoction Methotrexate Curative effect Inflammatory factors Joint function

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	LU Jidi GE Xianying WANG Hailin LI Xingrui▲

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LU Jidi GE Xianying WANG Hailin LI Xingrui▲. Effect of Guizhi Shaoyao Zhimu Decoction combined with Methotrexate in the treatment of cold-damp blockage syndrome of rheumatoid arthritis[J]. 中国医药导报, 2021, 18(18): 160-163.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I18/160

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