|
|
|
| Analysis on the medication rule of traditional Chinese medicine in the treatment of vertigo based on traditional Chinese medicine inheritance auxiliary platform |
| LIN Ling1 YUAN Jie2 LIU Dongling2 HAN Zucheng2 LUO Fan1 WANG Ying1 CHEN Jie2 |
1.The First Clinical College, Shaanxi University of Chinese Medicine, Shaanxi Province, Xianyang 712046, China;
2.Department of Encephalopathy, Shaanxi Traditional Chinese Medicine Hospital, Shaanxi Province, Xi’an 710003, China |
|
|
|
Abstract Objective To explore the medication rules of traditional Chinese medicine in the treatment of vertigo by using traditional Chinese medicine inheritance auxiliary platform. Methods The related literatures on the treatment of vertigo with traditional Chinese medicine from May 2015 to May 2020 in CNKI were searched. The theme with “vertigo” or “dizziness” and “Chinese medicine” or “traditional Chinese medicine” was advanced searched. The prescription was screened and the database was built. The frequency of drug use and drug pairs use, association rules and prescription rules were analyzed. Results Finally, 234 prescriptions were included, involved 235 kinds of traditional Chinese medicine, and the high-frequency drugs were Atractylodis Macrocephalae Rhizoma, Poria, Gastrodiae Rhizoma, Chuanxiong Rhizoma and Angelicae Sinensis Radix. The most commonly used traditional Chinese medicines were tonifying deficiency drugs, diuretic drugs, calming liver and calming wind drugs, promoting blood circulation and removing blood stasis drugs, etc. In terms of drug properties, the four qi was mainly warm and cold, the five flavors was mainly sweet and pungent, and the meridian tropism was mainly liver and spleen meridians. High frequency drug combinations included “Atractylodis Macrocephalae Rhizoma and Poria” “Atractylodis Macrocephalae Rhizoma and Gastrodiae Rhizoma” “Poria and Gastrodiae Rhizoma”, etc. Among the association rules between drugs, “Citri Reticulatae Pericarpium -> Atractylodis Macrocephalae Rhizoma” had the strongest association. Twelve core combinations and six new prescriptions were found. Conclusion Through excavation and analysis, it is concluded that the treatment of vertigo mainly includes regulating qi and activating blood circulation, drying dampness and resolving phlegm, calming liver yang, tonifying qi and blood, nourishing yin and kidney, which is in line with the principle of treating both symptoms and signs of traditional Chinese medicine. Its core combination and new prescription can provide reference for clinical medication and new drug research and development.
|
|
|
|
|
|
[1] Feigin VL，Forouzanfar MH，Krishnamurthi R，et al. Global and regional burden of stroke during 1990—2010：findings from the global burden of disease study 2010 [J]. Lancet，2014，383（9913）：245．
[2] Searls DE，Pazdera L，Korbel E，et al. Symptoms and signs of posterior circulation ischemia in the New England Medical Center posterior circulation registry [J]. Arch Neurol， 2012，69（3）：346．
[3] Minguez-Zuazo A，Grande-Alonso M，Saiz BM，et al. Therapeutic patient education and exercise therapy in patients with cervicogenic dizziness：a prospective case series clinical study [J]. J Exerc Rehabil，2016，12（3）：216-225．
[4] 曹德峰，陈文亚，吴波娜，等.瓜蒌皮注射液治疗眩晕的临床效果分析[J].中国医药科学，2019，9（24）：72-74.
[5] 戴万亨，张永涛.诊断学[M].北京：中国中医药出版社，2012：63-66.
[6] Neuhauser HK. The epidemiology of dizziness and vertigo [J].Handb Clin Neurol，2016，137：67-82.
[7] 周仲瑛.中医内科学[M].北京：中国中医药出版社，2003：312-319．
[8] 田代华.黄帝内经素问[M].北京：人民卫生出版社，2005：37-41.
[9] 王永炎，沈绍功.今日中医内科[M].北京：人民卫生出版社，1999：98．
[10] 魏子坚，蔡建群.中医辨证与常规西医治疗眩晕患者的疗效比较[J].内科，2017，12（5）：677-678，681.
[11] 陈湘君.中医内科学[M].上海：上海科学技术出版社，2001：125-130.
[12] 陈灏珠，林果为，王吉耀.实用内科学：下册[M].14版.北京：人民卫生出版社，2013：1337-1352.
[13] 卢朋，李健，唐仕欢，等.中医传承辅助系统软件开发与应用[J].中国实验方剂学杂志，2012，18（9）：1-4．
[14] 国家药典委员会.中华人民共和国药典[S].一部.北京：中国医药科技出版社，2015：336-337.
[15] 南京中医药大学.中药大辞典[M].2版.上海：上海科学技术出版社，2006：46-3834.
[16] 高学敏.中药学[M].北京：中国中医药出版社，2017.
[17] 唐仕欢，申丹，卢朋，等.中医传承辅助平台应用评述[J].中华中医药杂志，2015，30（2）：329-331.
[18] 李涵，杨明会，李绍旦.眩晕症病因病机的中医研究概况[J].中国继续医学教育，2018，10（12）：136-139.
[19] 李勤，刘宏.黄芪的药理作用及临床应用[J].医学综述，2004，10（10）：633.
[20] 吕琴，赵文晓，王世军，等.黄芪活血功效及现代药理学研究进展[J].中国实验方剂学杂志，2020，26（9）：215-224.
[21] 林少杰.天麻药理研究进展探析[J].亚太传统医药，2014， 10（2）：50-51.
[22] 安中原，钟斌.天麻的化学成分与药理活性研究概况[J].海峡药学，2017，29（6）：22-24.
[23] 章春华.活血祛瘀法治疗眩晕症临床举隅[J].中华现代中医学杂志，2008，4（4）：372-374.
[24] 金玉青，洪远林，李建蕊，等.川芎的化学成分及药理作用研究进展[J].中药与临床，2013，4（3）：44-48.
[25] 赵仁霞.丹参的现代药理研究及临床应用[J].中国医药指南，2011，9（12）：291.
[26] 吕丽华，荣晓慧.葛根活性成分的药理作用及其现代临床应用[J].社区医学杂志，2014，12（19）：35，81.
[27] 徐兆景.葛根素药理作用机制探讨及临床应用[J].中国现代药物应用，2016，10（8）：256-257.
[28] 李露，伍大华.半夏白术天麻汤加减治疗痰湿中阻型眩晕的临床疗效观察[J].中国社区医师，2020，36（2）：90-91.
[29] 王文涛.半夏白术天麻汤对椎-基底动脉供血不足眩晕临床症状及氧化应激的影响[J].实用中医内科杂志，2020， 34（7）：84-87. |
|
|
|
