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| Progress in studies on the correlation between intestinal flora and the pathogenesis of bipolar disorder |
| CONG Tongkuai PAN Miao |
| The Second Department of Mood Disorders, the Second Affiliated Hospital of Xinxiang Medical University, He’nan Province, Xinxiang 453000, China |
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Abstract Bipolar disorder is a major cause of economic burden and disability worldwide, but its underlying pathogenesis is still poorly understood, treatment is less effective and relapse is more likely. In recent years, more and more attention has been paid to the role of intestinal flora in bipolar disorder. The intestinal flora of patients with bipolar disorder changes, and it has two-way communicate with the brain through a variety of pathways, including immune inflammatory response, neuroendocrinology and nervous system, causing mood, energy levels and behavioral changes. Therefore, this paper reviews the research progress on intestinal flora and the pathogenesis of bipolar disorder, and provides new ideas for exploring the etiology, diagnosis, differential diagnosis and treatment of bipolar disorder.
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