外泌体在骨骼肌损伤修复中的研究进展

Abstract
Figure/Table
References (32)
Related Citation (15)

Download: PDF (517 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Skeletal muscle injury is a common clinical injury disease. The current treatment include traditional Chinese medicine and modern Western medicine, but these therapies have many problems. For example, massage and acupuncture have long treatment with poor efficacy, acupoint injection is easy to damage nerves, growth factor treatment can cause tumor-like malformations of muscle, stem cell transplantation may cause immune rejection, electrical stimulation results in mucosal injury and bleeding with poor durability. Exosomes are tiny vesicles rich in genetic substances and proteins, which play an important role in rebuilding injured muscles. As a novel therapy, exosomes can avoid the complications of the current treatments. Therefore, exosomes have broad prospects. This article reviews the current research progress of exosomes in rebuilding injured muscles.

Key words： Skeletal muscle Injury Exosomes Muscle regeneration

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHOU Min LI Bingshu LIU Cheng HONG Shasha HU Ming MIN Jie TANG Jianming HONG Li

Cite this article:

ZHOU Min LI Bingshu LIU Cheng HONG Shasha HU Ming MIN Jie TANG Jianming HONG Li. Research progress of exosomes in rebuilding injured muscles[J]. 中国医药导报, 2021, 18(18): 40-43.

URL:

https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I18/40

[1] 魏笑，孙茹.骨骼肌损伤治疗的研究进展[J].长春教育学院学报，2015，31（22）：31-32.
[2] Aswad H，Jalabert A，Rome S. Depleting extracellular vesicles from fetal bovine serum alters proliferation and differentiation of skeletal muscle cells in vitro [J]. BMC Biotechnol，2016，16（1）：1-12.
[3] Mobley CB，Mumford PW，McCarthy JJ，et al. Whey protein-derived exosomes increase protein synthesis and hypertrophy in C2C12 myotubes [J]. J Dairy Sci，2017，100（1）：48-64.
[4] Kalluri R，LeBleu VS. The biology，function，and biomedical applications of exosomes [J]. Science，2020，367（6478）：eaau6977.
[5] Valadi H，Ekstr?觟m K，Bossios A，et al. Exosome-mediated transfer of mＲNAs and microRNAs is a novel mechanism of genetic exchange between cells [J]. Nat Cell Biol，2007，9（6）：654-659.
[6] Baj-Krzyworzeka M，Szatanek R，W?誰glarczyk K，et al. Tumour-derived microvesicles carry several surface determinants and mRNA of tumour cells and transfer some of these determinants to monocytes [J]. Cancer Immunol Immunother，2006，55（7）：808-818.
[7] Salehi M，Sharifi M. Exosomal miRNAs as novel cancerbiomarkers：challenges and opportunities [J]. J Cell Physiol，2018，233（9）：6370-6380.
[8] Bhagirath D，Yang TL，Bucay N，et al. microRNA-1246 is an exosomal biomarker for aggressive prostate cancer [J]. Cancer Res，2018，78（7）：1833-1844.
[9] Zhao X，Wu D，Ma X，et al. Exosomes as drug carriers for cancer therapy and challenges regarding exosome uptake [J]. Biomed Pharmacother，2020，128：110237.
[10] Tao H，Xu H，Zuo L，et al. Exosomes-coated bcl-2 siRNA inhibits the growth of digestive system tumors both in vitro and in vivo [J]. Int J Biol Macromol，2020，161：470-480.
[11] Lemke G. How macrophages deal with death [J]. Nat Rev Immunol，2019，19（9）：539-549.
[12] Chazaud B. Inflammation during skeletal muscle regeneration and tissue remodeling：application to exercise-induced muscle damage management [J]. Immunol Cell Biol，2016，94（2）：140-145.
[13] Tidball JG. Regulation of muscle growth and regeneration by the immune system [J]. Nat Rev Immunol，2017，17（3）：165-178.
[14] Murphy C，Withrow J，Hunter M，et al. Emerging role of extracellular vesicles in musculoskeletal diseases [J]. Mol Aspects Med，2018，60：123-128.
[15] Prüller J，Mannhardt I，Eschenhagen T，et al. Satellite cells delivered in their niche efficiently generate functional myotubes in three-dimensional cell culture [J]. PLoS One，2018，13（9）：e0202574.
[16] Alameddine HS，Morgan JE. Matrix metalloproteinases and tissue inhibitor of metalloproteinases in inflammation and fibrosis of skeletal muscles [J]. J Neuromuscul Dis，2016，3（4）：455-473.
[17] Wosczyna MN，Rando TA. A muscle stem cell support group：coordinated cellular responses in muscle regeneration [J]. Dev Cell，2018，46（2）：135-143.
[18] Leoni G，Neumann PA，Kamaly N，et al. Annexin a1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair [J]. J Clin Invest，2015，125（3）：1215-1227.
[19] Bizzarro V，Petrella A，Parente L. Annexin A1：novel roles in skeletal muscle biology [J]. J Cell Physiol，2012，227（8）：3007-3015.
[20] Kim S，Lee MJ，Choi JY，et al. Roles of exosome-like vesicles released from inflammatory C2C12 myotubes：regulation of myocyte differentiation and myokine expression [J]. Cell Physiol Biochem，2018，48（5）：1829-1842.
[21] Forterre A，Jalabert A，Berger E，et al． Proteomic analysis of C2C12 myoblast and myotube exosome-like vesicles：a new paradigm for myoblast-myotube cross talk? [J]. PLoS One，2014，9（1）：e84153.
[22] Choi JS，Yoon HI，Lee KS，et al. Exosomes from differentiating human skeletal muscle cells trigger myogenesis of stem cells and provide biochemical cues for skeletal muscle regeneration [J]. J Control Release，2016，222：107-115.
[23] Guescini M，Maggio S，Ceccaroli P，et al. Extracellular vesicles released by oxidatively injured or intact C2C12 myotubes promote distinct responses converging toward myogenesis [J]. Int J Mol Sci，2017，18（11）：2488.
[24] Phinney DG，Di Giuseppe M，Njah J，et al. Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs [J]. Nat Commun，2015， 6：8472.
[25] Nakamura Y，Miyaki S，Ishitobi H，et al. Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration [J]. FEBS Lett，2015，589（11）：1257-1265.
[26] Fry CS，Kirby TJ，Kosmac K，et al. Myogenic progenitor cells control extracellular matrix production by fibroblasts during skeletal muscle hypertrophy [J]. Cell Stem Cell，2017，20（1）：56-69.
[27] Luo Y，Wu X，Ling Z，et al. microRNA133a targets Foxl2 and promotes differentiation of C2C12 into myogenic progenitor cells [J]. DNA Cell Biol，2015，34（1）：29-36.
[28] Cui S，Li L，Mubarokah SN，et al. Wnt/β-catenin signaling induces the myomiRs miR-133b and miR-206 to suppress Pax7 and induce the myogenic differentiation program [J]. J Cell Biochem，2019，120（8）：12740-12751.
[29] De Gasperi R，Hamidi S，Harlow LM，et al. Denervation-related alterations and biological activity of miRNAs contained in exosomes released by skeletal muscle fibers [J]. Sci Rep，2017，7（1）：12888.
[30] D’Souza RF，Woodhead JST，Zeng N，et al. Circulatory exosomal miRNA following intense exercise is unrelated to muscle and plasma miRNA abundances [J]. Am J Physiol Endocrinol Metab，2018，315（4）：E723-E733.
[31] Yan B，Zhang Y，Liang C，et al. Stem cell-derived exosomes prevent pyroptosis and repair ischemic muscle injury through a novel exosome/circHIPK3/FOXO3a pathway [J]. Theranostics，2020，10（15）：6728-6742.
[32] Guescini M，Guidolin D，Vallorani L，et al. C2C12 myoblasts release micro-vesicles containing mtdna and proteins involved in sign [J]. Exp Cell Res，2010，316：1977-1984.