Recurrent seizures of epilepsy are harmful to human health. Ganoderma mainly contains triterpenoids, polysaccharides, sterols, alkaloids, peptides and amino acids. Its antiepileptic effects can be manifested by inhibiting neuronal apoptosis, reducing nerve excitability, antioxidant stress, inhibiting the release of inflammatory factors, regulating the balance of neurotransmitters, promoting neuronal repair and synaptic remodeling, and improving learning, memory and cognitive functions, so protect nerve cells and inhibit seizure. The development of traditional antiepileptic drugs combined with traditional Chinese medicine can learn from each other’s strong points to make them more effective, more tolerable and safer, so as to promote the progress of epilepsy treatment, so that the antiepileptic effect is stronger, more tolerable and safer, to promote the progress of epilepsy treatment.