氟西汀治疗卒中后抑郁有效性和安全性的meta分析

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Abstract Objective To systematically evaluate the efficacy and safety of Fluoxetine in the treatment of post-stroke depression (PSD). Methods Literatures related to Fluoxetine in the treatment of PSD from PubMed, The Cochrane Library, CBM, CNKI, Wanfang Data and VIP were searched by computer. The retrieval time limit is from inception to September 2020. The literatures were selected according to the inclusion and exclusion criterias, the data was extracted and the literature quality was evaluated. RevMan 5.3 software was used for meta-analysis. Results A total of 763 patients were included in nine clinical randomized controlled studies. Meta-analysis results showed that the score of Hamilton depression scale in the Fluoxetine group was lower than that in the control group (SMD = -4.11, 95%CI [-5.31, -2.91], P ＜ 0.000 01). The score of national institute of health stroke scale in the Fluoxetine group was lower than that in the control group (SMD = -1.50, 95%CI [-2.41, -0.59], P = 0.001). There was no significant difference in the incidence of adverse reactions between Fluoxetine group and control group (RR = 2.11, 95%CI [0.05, 92.23], P = 0.70). Conclusion Fluoxetine can improve the depressive symptoms and neurological deficits in PSD patients without increasing the adverse reactions. However, whether this drug can be widely used in clinic still needs to carry out more high-quality studies to further prove the clinical efficacy.

Key words： Fluoxetine Post-stroke depression Meta-analysis Randomized controlled trial

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	WAND Dou1
	2 LI Tao1
	2 YANG Yifan1 MAO Meiling1 YAN Yongmei1
	2

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WAND Dou1,2 LI Tao1,2 YANG Yifan1 MAO Meiling1 YAN Yongmei1, et al. Meta-analysis on the efficacy and safety of Fluoxetine in the treatment of post-stroke depression[J]. 中国医药导报, 2021, 18(16): 74-77.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I16/74

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