糖皮质激素受体基因NR3C1 rs7701443和rs2963156多态性与脑小血管病的相关性分析

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Abstract Objective To explore the correlation between the glucocorticoid receptor gene (NR3C1) rs7701443 and rs2963156 polymorphisms and cerebral small vessel disease (CSVD). Methods Using the first-generation sequencing method, patients from the outpatient and inpatient of the Emergency General Hospital from March 2013 to May 2018 were selected and divided into the CSVD group (200 patients) and the control group (100 patients) based on the presence or absence of CSVD diagnosed by cranial MRI. The distribution of NR3C1 rs7701443 and rs2963156 polymorphisms were analyzed. Results There was no statistically significant difference in the frequency of rs7701443 between the two groups (P ＞ 0.05); after excluding the influence of CSVD risk factors such as hypertension, coronary heart disease and diabetes, the difference in the frequency of genotypes between the two groups was not statistically significant (P ＞ 0.05). There was no statistically significant difference in the frequency of rs2963156 between the two groups (P ＞ 0.05); after excluding the influence of CSVD risk factors such as hypertension, coronary heart disease, diabetes, etc., the difference in the frequency of genotypes between the two groups was not statistically significant (P ＞ 0.05). Conclusion The polymorphisms of rs7701443 and rs2963156 of NR3C1 may not be related to the onset of CSVD.

Key words： Glucocorticoid receptor gene Single nucleotide polymorphism Cerebral small vessel disease Risk factors Correlation

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	LI Jingya1
	2 WANG Jun1 MO Weiyan1 REN Xin1 WANG Qi1 ZHOU Weidong1

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LI Jingya1,2 WANG Jun1 MO Weiyan1 REN Xin1 WANG Qi1 ZHOU Weidong1. Correlation analysis between glucocorticoid receptor gene NR3C1 rs7701443, rs2963156 polymorphisms and cerebral small vessel disease[J]. 中国医药导报, 2021, 18(16): 42-45.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I16/42

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