三阴性乳腺癌组织中FOXJ1、SATB1的表达变化及临床意义

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Abstract Objective To investigate the relationship between the expression of forkhead box J1 (FOXJ1) and special AT rich sequence binding protein 1 (SATB1) and clinicopathological parameters and prognosis of triple negative breast cancer. Methods A total of 98 patients with triple negative breast cancer admitted to the Third Hospital of Nanchang from February 2014 to March 2015 were selected as study subjects. Cancer tissues and paracancerous tissues were collected for use. The expression of FOXJ1 and SATB1 and their relationship with clinicopathological parameters were analyzed. The difference of five-year overall survival rate among patients with different FOXJ1, SATB1 expression were analyzed by Kaplan-Meier survival curve. Results The positive rate of FOXJ1 in triple negative breast cancer tissues was lower than that in paracancerous tissues (P < 0.01); and the positive rate of SATB1 was higher than that of paracancerous tissues (P < 0.01). In triple negative breast cancer tissues, different FOXJ1 expression was correlated with TNM stage and tumor differentiation degree (P < 0.05 or P < 0.01); different SATB1 expression was associated with the depth of tumor invasion, TNM stage, and whether lymph node metastasis (P < 0.05 or P < 0.01). The expression of FOXJ1 was negatively correlated with the expression of SATB1 in triple negative breast cancer (r = -0.625, P < 0.05). The five-year overall survival rate of FOXJ1 positive patients was higher than that of negative patients, while the five-year overall survival rate of SATB1 positive patients was lower than that of negative patients (all P < 0.01). Conclusion The low expression of FOXJ1 and high expression of SATB1 in triple-negative breast cancer tissues are both involved in the occurrence and development of triple negative breast cancer, and are correlated with the prognosis of patients with triple negative breast cancer. Detection the expression of FOXJ1 and SATB1 are helpful for the prognosis evaluation of patients.

Key words： Triple negative breast cancer Forkhead box J1 Special AT rich sequence binding protein 1 Prognosis

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	FU Feiguo WANG Yili LEI Qiumo

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FU Feiguo WANG Yili LEI Qiumo. Expression of FOXJ1 and SATB1 in triple negative breast cancer and its clinical significance[J]. 中国医药导报, 2021, 18(16): 38-40,51.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I16/38

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