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| Study on medication rule of traditional Chinese medicine in treating precocious puberty of girls based on literature |
| GUO Chunyan1 ZHANG Meng1 LIU Jing2 BAI Guoliang1 ZHAO Libo1 |
1.Clinical Research Center, National Center for Children Health Beijing Children’s Hospital, Capital Medical University, Beijing 100045, China;
2.Department of Traditional Chinese Medicine, National Center for Children Health Beijing Children’s Hospital, Capital Medical University, Beijing 100045, China |
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Abstract Objective To analyze the medication rule of traditional Chinese medicine in treating precocious puberty of girls based on data mining method. Methods From the database establishment to June 2020, the published journals in China biomedical literature service system, China journal full text database, Wanfang data knowledge service platform, VIP Chinese science and technology journal database, PubMed and ScienceDirect were searched by computer. The data was input into the ancient and modern medical record cloud platform (V2.2.3) to analyze the medication rules of traditional Chinese medicine in the treatment of girls’ precocious puberty, and compared with Fuyou Mixture. Results A total of 3332 Chinese literatures, 21 Western literatures and 213 included literatures were searched, including 226 prescriptions. The main traditional Chinese medicine syndrome was yin deficiency and fire hyperactivity. The frequency of traditional Chinese medicine from high to low was Anemarrhenae Rhizoma, Rehmanniae Radix, Phellodendri Chinensis Cortex, Moutan Cortex, Prunellae Spica. The common Chinese medicines were mainly cold and bitter in nature, and mostly belong to liver and kidney channels. The core prescription was Zhibai Dihuang Pills, there were four kinds of traditional Chinese medicine with Fuyou Mixture. Conclusion The principle of traditional Chinese medicine in treating precocious puberty of girls is liver, spleen and kidney. Based on this result, we plan to add Anemarrhenae Rhizoma and Phellodendri Chinensis Cortex to improve Fuyou Mixture.
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