妊娠晚期B群链球菌定植情况、抗菌药物敏感性及妊娠结局分析

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Abstract Objective To analyze the colonization and antimicrobial susceptibility of Group B Streptococcus (GBS) in the third trimester of pregnancy and its pregnancy outcome. Methods The medical records of 500 pregnant women who voluntarily underwent vaginal combined rectal GBS screening in the Second Affiliated Hospital of Anhui Medical University from January to September 2020 were retrospectively analyzed. The colonization of GBS and the antimicrobial susceptibility of GBS positive samples were analyzed. According to the results of GBS screening, they were divided into GBS negative group and GBS positive group, and the pregnancy outcome of two groups was compared. Results A total of 56 pregnant women with GBS positive were detected among 500 pregnant women, and the colonization rate was 11.20%; among which 41 were positive vaginal specimens, the colonization rate was 8.20%; there were 32 positive rectal specimens, the colonization rate was 6.40%. GBS had high resistance to Clindamycin, Erythromycin and Tetracycline, and high sensitivity to Cefuroxime, Linezolid, Vancomycin, Ampicillin and Penicillin. The proportion of prenatal fever, abnormal pregnancy history of GBS positive group were higher than those of GBS negative group, and the differences were statistically significant (all P < 0.05). The proportions of premature rupture of membranes, puerperium infection, postpartum hemorrhage, neonatal septicemia and neonatal pneumonia in GBS positive group were higher than those in GBS negative group, and the differences were statistically significant (all P < 0.05). Conclusion The overall colonization rate of GBS is low in the third trimester of pregnancy, and the detection rate of GBS can be increased by comprehensive rectal examination. GBS positive patients have higher adverse pregnancy outcomes such as premature rupture of membranes, puerperal infection, Prenatal fever postpartum hemorrhage, neonatal septicemia, and neonatal pneumonia. GBS has high sensitivity to Cefuroxime, Linezolid, Vancomycin, Ampicillin and Penicillin.

Key words： Group B Streptococcus Third trimester of pregnancy Colonization Antimicrobial Pregnancy outcome Susceptibility

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	SONG Yurong ZHAN Lei SUN Li

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SONG Yurong ZHAN Lei SUN Li. Analysis of colonization of Group B Streptococcus, antimicrobial susceptibility and pregnancy outcome in the third trimester of pregnancy[J]. 中国医药导报, 2021, 18(15): 113-116.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I15/113

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