补气益肾活血法联合介入治疗早中期股骨头坏死的临床效果

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Abstract Objective To explore the clinical effect of Buqi Yishen Huoxue method combined with interventional therapy on early and middle stage femoral head necrosis. Methods A total of 120 patients with early and middle stage femoral head necrosis admitted to Liaocheng Traditional Chinese Medicine Hospital, Shandong Province, from June 2018 to June 2020 were selected. They were divided into control group and observation group by random number table method, with 60 cases in each group. The control group was treated with selective vascular drug interventional therapy, and the observation group was treated with Buqi Yishen Huoxue method on the basis of control group. Both groups were treated continuously for one month. Clinical efficacy and the incidence of adverse reactions were compared between two groups. Traditional Chinese medicine (TCM) syndrome scores, bone metabolism indexes before and after treatment, and hip joint function after three months follow-up were compared between the two groups. Results The total effective rate and the excellent and good rate of hip joint function in the observation group were higher than those in the control group, with statistical significance (all P ＜ 0.05). After treatment, TCM syndrome score, Ⅰ type collagen cross-linked carboxy-terminal peptide (CTX-Ⅰ) and tartrate-resistant acid phosphatase (TRAP) in two groups were lower than those before treatment, serum osteocalcin (BGP) and Ⅰ type collagen amino-terminal elongation peptide (PⅠNP) were higher than those before treatment, and TCM syndrome score, CTX-Ⅰ and TRAP in the observation group were lower than those in the control group, BGP and PⅠNP were higher than those in the control group, and the differences were statistically significant (all P ＜ 0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Buqi Yishen Huoxue method combined with interventional therapy on early and middle stage femoral head necrosis can improve the TCM syndrome, promote the improvement of bone metabolism indexes, and help alleviate hip function without increasing adverse reactions, with high safety.

Key words： Buqi Yishen Huoxue method Early and middle stage necrosis of femoral head necrosis Bone metabolism index Hip function Adverse reaction

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	LIU Xiaozhi1 HU Xuefei2 ZHENG Dawei1 LIU Fei1 LIU Gang1

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LIU Xiaozhi1 HU Xuefei2 ZHENG Dawei1 LIU Fei1 LIU Gang1. Clinical effect of Buqi Yishen Huoxue method combined with interventional therapy on early and middle stage femoral head necrosis[J]. 中国医药导报, 2021, 18(15): 100-103,108.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I15/100

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