尿毒清颗粒联合氢氯噻嗪治疗慢性肾功能衰竭的临床研究

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Abstract Objective To investigate the clinical effect of Niaoduqing Granules combined with Hydrochlorothiazide in the treatment of chronic renal failure (CRF). Methods A total of 126 patients with CRF in Fuyang Second People’s Hospital from January 2018 to January 2020 were selected, they were divided into control group (63 cases) and observation group (63 cases). The control group was treated with Hydrochlorothiazide, and the observation group was treated with Nuiduqing Granules combined with Hydrochlorothiazide, the course of treatment was 8 weeks. The effect and symptom improvement time after treatment were recorded. Inflammatory factors, renal function indexes and adverse reactions during treatment were compared between the two groups before and after treatment. Results The total effective rate of observation group was higher than that of control group (P ＜ 0.05). The improvement time of fatigue, edema, anorexia and nausea in the observation group were shorter than those in the control group (P ＜ 0.05). After 8 weeks of treatment, the levels of interleukin-1β, creatinine, tumor necrosis factor-α, urea nitrogen and interleukin-6 in both groups were decreased than before treatment, and the observation group was lower than the control group (P ＜ 0.05). Compared with before treatment, after 8 weeks of treatment, the clearance rate of endogenous creatinine in both groups was increased, and the observation group was higher than the control group (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Niaoduqing Granules combined with Hydrochlorothiazide in the treatment of CRF patients can effectively promote the improvement of symptoms, reduce the micro inflammatory state, delay the process of renal failure, which is safe and reliable, and the curative effect is worthy of recognition.

Key words： Niaoduqing Granules Hydrochlorothiazide Chronic renal failure Clinical research

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	WEI Ping1 JIANG Chuanxue2 SUN Xiangrui3

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WEI Ping1 JIANG Chuanxue2 SUN Xiangrui3. Clinical study of Niaoduqing Granules combined with Hydrochlorothiazide in the treatment of chronic renal failure[J]. 中国医药导报, 2021, 18(15): 92-95.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I15/92

[1] 万文杰，项方羽.高通量血液透析对老年慢性肾衰竭患者微炎症反应和肾功能的影响[J].中国老年学杂志，2020， 40（6）：1284-1287.
[2] 毕秘密，张航.生脉注射液联合米力农注射液对慢性心力衰竭患者心肾功能的影响[J].世界中医药，2020，15（9）：1326-1330.
[3] 董萌.沙库巴曲缬沙坦钠治疗老年慢性心力衰竭合并肾功能不全患者的临床观察[J].中国中西医结合急救杂志，2020，27（1）：84-87.
[4] 石媛，何红权.自拟桂蓉汤治疗慢性肾衰竭的疗效及对肾功能的改善作用[J].中国中医药科技，2020，27（3）：497-499.
[5] 马媛媛，穆红光，王晓寅，等.尿毒清颗粒联合非布司他治疗慢性肾病的疗效观察[J].河北医药，2020，42（12）：1870-1873.
[6] 复旦大学上海医学院.实用内科学-第13版[J].中国医刊，2009，44（12）：43.
[7] 中华人民共和国卫生部.中药新药临床研究指导原则[M].北京：中国医药科技出版社，2001：163-167.
[8] 朱晓婷，陈志强，张亚楠，等.益气化湿通络方通过调节NF-κB信号通路改善慢性肾功能衰竭大鼠炎性纤维化的实验研究[J].中草药，2020，51（8）：2193-2199.
[9] 刘楠，孙荣嵘，冯小华，等.白藜芦醇对慢性肾功能衰竭模型肾纤维化作用的机制研究[J].中国临床药理学杂志，2019，35（15）：1609-1612.
[10] 周瑞琴，孟国正.海昆肾喜胶囊联合氢氯噻嗪治疗慢性肾功能衰竭的临床研究[J].现代药物与临床，2019，34（8）：2458-2462.
[11] 钱虹利，廖威，孟立锋，等.尿毒清颗粒对腹膜透析患者临床疗效及安全性的系统评价与Meta分析[J].辽宁中医杂志，2020，47（2）：33-40.
[12] 吴琳虹，陈兴强，张萌，等.尿毒清颗粒联合苯溴马隆对高尿酸血症患者血管内皮功能及炎性反应的影响[J].中国药业，2019，28（12）：76-78.
[13] 岳英丽，陈珊珊，窦晓丽.尿毒清颗粒联合左卡尼汀注射液治疗急性肾衰竭浊瘀阻塞证的临床研究[J].河北中医，2019，41（6）：880-885.
[14] 朱俊利.百令胶囊对慢性肾功能衰竭透析患者营养状况、炎性细胞因子水平的影响[J].新中医，2019，51（8）：154-156.
[15] 程小丽，杨世峰，师锁江，等.黄芪附子方治疗慢性肾功能衰竭维持性血液透析疗效及对患者氧化应激、微炎症反应和生活质量的影响[J].陕西中医，2020，41（10）：1436-1439.
[16] 杨洁，张霄娜.慢性心力衰竭患者血清炎症因子水平与心功能分级及肾功能损害程度的相关性分析[J].检验医学与临床，2019，16（7）：919-922.
[17] 戴红梅，朱义芳.慢性心力衰竭患者血清TNF-α、BNP、Cys-C水平与心肾功能的关系[J].中国医药导报，2019， 16（16）：155-158，162.
[18] 刘鹏，桂壮，邵治国.不同剂量大黄附子细辛汤对慢性肾功能衰竭脾肾阳虚证患者肾功能、CRP、IL-6及TNF-α的影响[J].湖南中医药大学学报，2019，39（5）：640-643.
[19] 李瑞婷，程慧，刘小方，等.慢性心力衰竭合并贫血患者Fe、TNF-α、IL-6、IL-1β与铁调素的水平及相关性研究[J].中国医药科学，2020，10（20）：25-29.
[20] 田江辉，柴广军.慢性肾衰患者血清TNF-α、SIL-2R、IL-1β测定及其意义[J].标记免疫分析与临床，2014， 21（6）：789-790.
[21] 殷佳珍，朱斌，陈洪宇，等.尿毒清颗粒治疗慢性肾脏病3～5期的Meta分析[J].中国中西医结合肾病杂志，2020， 21（2）：136-142.
[22] 闫丽君，赵景新，刘士英，等.健脾益肾泄浊汤灌肠治疗慢性肾衰竭脾虚湿浊证的疗效观察及对患者肾功能、钙磷代谢水平的影响[J].河北中医，2019，41（5）：693-697.
[23] 郭雪.辛伐他汀辅助肾康注射液对慢性肾衰竭患者肾功能、血脂及免疫功能的影响[J].中国老年学杂志，2019， 39（13）：3214-3217.
[24] 张瑶琳，葛琪容，罗海波，等.托伐普坦联合尿毒清颗粒治疗肾病综合征的临床效果[J].疑难病杂志，2020，19（1）：49-52.
[25] 孙军院，孙媛媛，陈磊鑫，等.尿毒清颗粒联合西药治疗慢性肾功能衰竭的临床疗效及对患者免疫功能的影响[J].贵州医药，2020，44（2）：261-263.
[26] 杨静.基于JAK2/STAT3信号通路研究芍药苷抑制糖尿病肾脏巨噬细胞激活的分子机制[D].合肥：安徽医科大学，2018.