Correlation between homocysteine and blood glucose fluctuation in patients with type 2 diabetes with vascular complications
CAI Qian1 LI Yuncheng2 LI Wei2
1.Graduate School, Xuzhou Medical University, Jiangsu Province, Xuzhou 221004, China;
2.Department of Endocrinology, the Affiliated Hospital of Xuzhou Medical University, Jiangsu Province, Xuzhou 430071, China
Abstract Objective To explore the relationship between homocysteine (Hcy) and blood glucose fluctuations in patients with type 2 diabetes with vascular complications. Methods A retrospective analysis of the clinical data of 497 patients with type 2 diabetes who were admitted to the Affiliated Hospital of Xuzhou Medical University from July 2017 to April 2019. According to the presence or absence of vascular complications, the selected subjects were divided into group A (without vascular complications, 162 cases), and group B (with vascular complications, 335 cases). In addition, the patients were divided into four groups according to the Hcy quartile. Among them, Hcy≤11.0 μmol/L was the Q1 group (103 cases), 11.0 μmol/L＜Hcy≤14.2 μmol/L was the Q2 group (157 cases), 14.2 μmol/L <Hcy≤19.0 μmol/L was the Q3 group (121 cases), and Hcy>19.0 μmol/L was the Q4 group (116 cases). The relative indicators of blood glucose fluctuations among the groups were compared. Results The age, course of disease, systolic blood pressure (SBP), Hcy, maximum blood glucose fluctuation range (LAGE), postprandial blood glucose fluctuation range (PPGE), and average blood glucose standard deviation (SDBG) in group B were higher than those in group A, and the differences were statistically significant (P ＜ 0.05). There were statistically significant differences in age, course of disease, SBP, SDBG, MBG, LAGE, HOMA-β, and HbA1c in the Q1-Q4 groups (P ＜ 0.05). Among them, age, course of disease, HbA1c, SDBG, MBG, LAGE of Q4 group were higher than those of the other three groups, Q3 group was higher than Q1, Q2 group, Q2 group was higher than Q1 group, and the differences were statistically significant (P ＜ 0.05). SBP of Q4 group was higher than Q1 and Q3 group, lower than Q2 group; Q3 group was higher than Q1 group, lower than Q2 group; Q2 group was higher than Q1 group, and the differences were statistically significant (P ＜ 0.05). HOMA-β in Q4 group were higher than Q1 group, lower than Q2 and Q3 group; Q3 group was higher than Q1 group, lower than Q2 group, Q2 group was higher than Q1 group, and the differences were statistically significant (P ＜ 0.05). Correlation studies showed that Hcy was negatively correlated with body mass index, diastolic blood pressure, and total cholesterol (P ＜ 0.05); it was positively correlated with age, SBP, HbA1c, LAGE, MBG, fasting blood glucose, PPGE, SDBG, and the course of diabetes (P ＜ 0.05). Conclusion Patients with type 2 diabetes have large fluctuations in blood glucose and increased Hcy, suggesting that it may increase the risk of diabetes complicated with vascular complications.
CAI Qian1 LI Yuncheng2 LI Wei2. Correlation between homocysteine and blood glucose fluctuation in patients with type 2 diabetes with vascular complications[J]. 中国医药导报, 2021, 18(15): 71-74.
