草酸艾司西酞普兰与舍曲林分别联合认知行为治疗青少年抑郁症的临床对照研究

Abstract
Figure/Table
References (28)
Related Citation (15)

Download: PDF (394 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the clinical efficacy of Escitalopram Oxalate and Sertraline combined with cognitive behavior in the treatment of adolescent depression. Methods A total of 70 cases with adolescent depression treated in the third people’s Hospital of Fuyang City, Anhui Province from May 2017 to September 2020 were selected as the object of study. According to the random number table method, they were divided into the control group and the observation group, with 35 cases in each group. The control group was treated with Sertraline combined with cognitive behavioral therapy; the observation group was treated with Escitalopram Oxalate combined with Cognitive behavioral therapy. After four weeks of continuous treatment, the severity of the disease and clinical efficacy were evaluated by hamilton depression scale (HAMD) and hamilton anxiety scale (HAMA), and the safety of drugs was evaluated by treatment emergent symptom scale (TESS). Results There was no significant difference in the total effective rate between the two groups after four weeks of treatment (P ＞ 0.05); the scores of HAMD and HAMA were different in different time and group, and there was interaction between time and group, and the difference was statistically significant (all P ＜ 0.05); further pairwise comparison showed that there were significant differences in HAMD and HAMA scores before treatment, the second week and the fourth week of treatment (P ＜ 0.05); there was no significant difference in the scores of HAMD and HAMA between the two groups before treatment, the second week of treatment and the fourth week of treatment (P ＜ 0.05); there was no significant difference in the incidence of ADR between the two groups (P ＞ 0.05). Conclusion Escitalopram Oxalate and Sertraline combined with cognitive behavior therapy in adolescent patients with depression had satisfactory clinical effects and good tolerance, but sertraline had more adverse reactions.

Key words： Escitalopram Oxalate Sertraline Cognitive behavior Adolescent depression

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZOU Liang1 ZHANG Xingong2 SUN Lili3 ZHANG Lingling4▲ WANG Hanyu2

Cite this article:

ZOU Liang1 ZHANG Xingong2 SUN Lili3 ZHANG Lingling4▲ WANG Hanyu2. Clinical control study of Escitalopram Oxalate and Sertraline combined with cognitive behavior in the treatment of adolescent depression[J]. 中国医药导报, 2021, 18(13): 141-144.

URL:

https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I13/141

[1] 朱培俊，唐琳，杨国平.草酸艾司西酞普兰联合小剂量奥氮平治疗抑郁症的疗效与安全性观察[J].贵州医药，2018，42（8）：987-988.
[2] 赵洪国，王伟，张秀泉，等.草酸艾司西酞普兰联合激素补充治疗女性更年期抑郁症合并高血压前期的临床疗效[J].国际精神病学杂志，2017，43（2）：274-276.
[3] 卢伟明.艾司西酞普兰与舍曲林治疗脑卒中后抑郁患者的疗效及对炎症因子、NSE、NPY的影响[J].中华全科医学，2017，15（8）：1340-1341，1401.
[4] 世界卫生组织.ICD-10精神与行为障碍分类[M].范肖东，汪向东，等.译.北京:人民卫生出版社，1993.
[5] 张明园.精神科评定量表手册[M].长沙：湖南科学技术出版社，1998：125-128.
[6] 喻东山.减分率公式的修正[J].临床精神医学杂志，1995， 1：12.
[7] 张明园.副反应量表（TESS）[J].上海精神医学，1984，25（2）：687-689.
[8] 钱淑霞，岳卫清，张晓玲，等.豁痰清窍解郁汤，草酸艾司西酞普兰片口服及综合康复治疗卒中后抑郁患者的临床效果[J].中华中医药学刊，2016，34（5）：1148-1150.
[9] Levy MJF，Fabien B，Steinbusch HW，et al. Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression [J]. Psychopharmacology （Berl），2018，235（8）：2195-2220.
[10] 王娜，毛佩贤，李占江.认知行为治疗或支持性心理治疗联合药物治疗老年抑郁症的随机对照研究[J].中华精神科杂志，2017，50（5）：371-376.
[11] Tshitangano TG，Pengpid S，Peltzer K. Prevalence of prenatal depression and associated factors among HIV-positive women in primary care in Mpumalanga province，South Africa [J]. Nova Hedwigia，2018，99（2）：75-85.
[12] 阎丹峰，李凌江.抑郁症患者的认知功能障碍及其临床启示[J].中华精神科杂志，2018，51（5）：343-346.
[13] 张一靓，钟舒明，赖顺凯，等.抑郁症视觉认知功能损伤的脑影像研究[J].中华行为医学与脑科学杂志，2019， 28（10）：951-955.
[14] Obbels J，Verwijk E，Vansteelandt K，et al. Long-term neurocognitive functioning after electroconvulsive therapy in patients with late-life depression [J]. Acta Psychiatr Scand，2018，138（3）：223-231.
[15] Monden R，Roest AM，Van Ravenzwaaij D，et al. The comparative evidence basis for the efficacy of second-generation antidepressants in the treatment of depression in the US：A Bayesian meta-analysis of Food and Drug Administration reviews [J]. J Affect Disord，2018，1（235）：393-398.
[16] 胡蕊，宋美，宋志领，等.奥氮平片联合艾司西酞普兰片治疗老年抑郁症的临床研究[J].中国临床药理学杂志，2017，32（19）：1900-1902.
[17] 鲍莎莎，宋哲，张金峰，等.艾司西酞普兰治疗老年抑郁症临床观察[J].解放军医药杂志，2019，31（4）：107-109.
[18] 石娟娟，沈莉，李鸿娜，等.解郁通脉汤治疗冠脉支架术后抑郁症68例临床观察[J].天津中医药，2016，33（3）：139-143.
[19] 尹丽敏，张忠臣，刘津麟.盐酸舍曲林片治疗溃疡性结肠炎合并抑郁症的疗效观察[J].中华全科医学，2016， 14（5）：810-813.
[20] 王西建，李琨，焦宁波，等.艾司西酞普兰联合解郁安神颗粒治疗抑郁症的效果及对患者血清IL-2、IL-6、TNF-α、Hcy水平的影响水[J].现代生物医学进展，2017， 34（17）：5127.
[21] 林翔，房圆，李霞.老年人抑郁症与认知障碍的鉴别诊断和临床诊治[J].中华老年医学杂志，2017，36（1）：12-13.
[22] 王静，胡艳丽，徐伟杰，等.艾司西酞普兰治疗40例原发性失眠对患者的睡眠改善效果及不良反应研究[J].中华全科医学，2016，14（4）：583-584.
[23] 舒燕萍，况利，黄乾坤，等.认知行为治疗联合氟西汀治疗对自杀未遂青年抑郁症患者脑区比率低频振幅的影响[J].中华精神科杂志，2020，53（5）：392-399.
[24] 肖刚，陆德青，吴小未，等.艾司西酞普兰合用奥氮平治疗更年期难治性抑郁症的随机对照研究[J].中国临床医生杂志，2016，6（16）：33-35.
[25] 陈艳波，杨艳，张丽娜.米氮平联合艾司西酞普兰对抑郁症患者情绪，睡眠质量及认知功能的影响[J].中国医师杂志，2020，22（4）：580-583.
[26] 张霞，李云霞，张艳，等.疏肝解郁胶囊与舍曲林治疗老年轻中度抑郁症对照研究[J].中国医药导报，2020，17（32）：116-119.
[27] 庞兆烽，徐武华，吴婉霞，等.甜梦胶囊联合盐酸舍曲林片治疗脑卒中后抑郁症的效果[J].中国医药导报，2020， 17（2）：65-68.
[28] 刘玉芝，寇海燕.肿瘤坏死因子-α基因多态性与首发抑郁症及舍曲林疗效的关联研究[J].中国当代医药，2020，27（26）：17-23.