DTI-TBSS对鼻咽癌患者放疗前后脑白质变化的评价价值

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Abstract Objective To explore the value of magnetic resonance diffusion tensor imaging (DTI)-fiber tract tracer based spatial design (TBSS) in evaluating white matter in nasopharyngeal carcinoma patients before and after radiotherapy. Methods Thirty-four patients with nasopharyngeal carcinoma admitted to Lishui Hospital of Traditional Chinese Medicine, Zhejiang Province from September 2019 to April 2020 were selected. DTI-TBSS was used to analyze the anisotropy score (FA), mean diffusion coefficient (MD), value of λ‖ and λ⊥ of white matter before and after radiotherapy. Mini-mental state examination (MMSE) scores were compared before radiotherapy and six months after radiotherapy. Results After six months of radiotherapy, the FA values of white matter in the right parietal lobe, right occipital lobe and right frontal lobe were all lower than those before radiotherapy. The MD values of whit matter in the right occipital lobe, temporal lobes, the left and right parietal lobes were higher than those before radiotherapy. The value of λ‖ in white matter of the right temporal lobe, the left occipital lobe, the left temporal lobe, the left parietal lobe and the right parietal lobe were lower than before radiotherapy. The value of λ⊥in the right occipital lobe, the left fronto-parietal boundary and the left parietal lobe were all higher than those before radiotherapy, while the value of λ⊥ in the right cerebellum white matter and the left hemioval center were all lower than those before radiotherapy; MMSE score was lower than that before radiotherapy, and the differences were all statistically significant (all P ＜ 0.05). The FA value of white matter in the right occipital (r = 0.383, P ＜ 0.05) and the λ‖ value of white matter in the right parietal white matter (r = 0.391, P ＜ 0.05) were positively correlated with the MMSE score after radiotherapy, while the value of λ⊥ in the left fronto-parietal boundary (r = -0.404, P ＜ 0.05) and MD value (r = -0.411, P ＜ 0.05) were negatively correlated with the MMSE score after radiotherapy. Conclusion DTI-TBSS can be used to evaluate the white matter damage in patients with nasopharyngeal carcinoma after radiotherapy, which is helpful for the diagnosis of radiation brain injury.

Key words： Magnetic resonance diffusion tensor imaging Space design based on fiber tracer Nasopharyngeal carcinoma Radiotherapy

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	XU Shida WANG Qingchun ZHANG Hongyang▲

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XU Shida WANG Qingchun ZHANG Hongyang▲. Value of DTI-TBSS in evaluating changes of white matter in patients with nasopharyngeal carcinoma before and after radiotherapy[J]. 中国医药导报, 2021, 18(13): 133-136.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I13/133

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