1号中药洗剂对肛周脓肿术后创面愈合疗效及血清炎症因子的影响

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Abstract Objective To observe the effect of No.1 traditional Chinese medicine lotion on wound healing and serum inflammatory factors after perianal abscess operation. Methods Eighty-four patients with perianal abscess in Department of Anorectal, Shenzhen Anorectal Hospital of Traditional Chinese Medicine from February to June 2018 were selected and divided into control group and observation group according to random number table method, 42 cases in each group. Two groups were given Ceftazidime for injection for three days after operation, while control group was given potassium permanganate lotion hip bath, and observation group was given No.1 traditional Chinese medicine lotion hip bath. Two groups were given the same rehydration, acid-base balance adjustment drugs, symptomatic support treatment after operation. Clinical efficacy, wound healing time, wound edema disappearance time, visual analogue scale (VAS) and serum inflammatory factors were compared between two groups. Results There was no significant difference in clinical efficacy between two groups (P > 0.05). The wound healing time and wound edema disappearance time of observation group were shorter than those of control group, and the difference was statistically significant (P < 0.05). There were significant differences in VAS on group comparison, time point comparison and interaction (P < 0.05). There was significant difference in VAS between two groups at different time points (P < 0.05). The levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in two groups at 10 days after operation were lower than those at one day after operation, and the differences were statistically significant (P < 0.05). The levels of IL-6 and TNF-α in observation group at one day and 10 days after operation were lower than those in control group (P < 0.05). Conclusion No.1 traditional Chinese medicine lotion can significantly improve the wound healing of patients with perianal abscess, reduce the pain of patients, promote wound healing, reduce the level of serum inflammatory factors, and reduce the risk of postoperative re infection, which is worthy of clinical promotion.

Key words： Perianal abscess Fumigation Chinese medicine Clinical observation

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	ZHANG Chaoyang1 LIANG Jinghua2 SUN Linmei3 LI Pu1 FEI You1

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ZHANG Chaoyang1 LIANG Jinghua2 SUN Linmei3 LI Pu1 FEI You1. Effect of No.1 traditional Chinese medicine lotion on wound healing and serum inflammatory factors after perianal abscess operation[J]. 中国医药导报, 2021, 18(13): 121-124.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I13/121

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