布鲁菌病临床特征分析

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Abstract Objective To analyze the differences in clinical manifestations and laboratory data of 219 patients with brucellosis collected in the Fifth Hospital of Shijiazhuang City, and to provide the scientific basis for the prevention and treatment of brucellosis. Methods A total of 219 patients with brucellosis admitted to the Fifth Hospital of Shijiazhuang City from January 2016 to December 2018 were collected as the research objects. According to different age groups, they were divided into ＜20 years old, 20-＜40 years old, 40-60 years old and ＞60 years old groups. The number of patients in the four groups was 9, 43, 105 and 62, respectively. The abnormal rates of CD3+T cells, CD4+T cells, CD8+T cells and CRP in four groups were compared. The incidence of complications in four groups was compared. Results There were statistically significant differences in the abnormal rates of CD3+T cells, CD4+T cells and C reactive protein (CRP) among the four groups (all P ＜ 0.05), while there were no statistically significant differences in the abnormal rates of CD8+T cells among the four groups (P ＞ 0.05). Further pair comparison showed that the abnormal rate of CD3+T cells in ＞60 years old group was lower than that in 40-60 years old group, and the abnormal rate of CD4+T cells in 40-60 years group was lower than that in 20-＜ 40 years old and ＞60 years old group, and the abnormal rate of CRP in 20-＜ 40 years old group was lower than that in 40-60 years old group and ＞60 years old group, and the differences were all statistically significant (all P ＜ 0.008). There were statistically significant differences in liver diseases, orchitis, lumbar osteogeny and pulmonary infection among the four groups (all P ＜ 0.05). There was no significant difference in the incidence of disc herniation and hypertension among the four groups (P ＞ 0.05). Further pair comparison showed that the incidence of liver disease and orchitis in ＞60 years old group was higher than that in 20-＜40 years old group and 40-60 years old group and the incidence of lumbar osteopenia was higher than that in ＜20 years old group, 20-＜40 years old group and 40-60 years old group. The incidences of pulmonary infection in the 20-＜40 and 40-60 groups were all lower than those in the ＜20 group, and the differences were statistically significant (all P ＜ 0.008). Conclusion The test results of T cell subsets can provide a basis for judging the immune status of patients with brucellosis, and the CRP value is used as an auxiliary index to judge the severity of inflammation in patients with brucellosis.

Key words： Brucella Brucellosis Clinical manifestations T cell subsets C reactive protein

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	TIAN Yueyang GAO Huixia SUN Qian LI Yanfeng ZHANG Zhi

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TIAN Yueyang GAO Huixia SUN Qian LI Yanfeng ZHANG Zhi. Analysis of clinical characteristics of brucellosis[J]. 中国医药导报, 2021, 18(13): 89-92.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I13/89

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