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| Application of blood GM test combined with bronchoscope alveolar lavage fluid in the diagnosis of pulmonary aspergillosis |
| ZHOU Yongjun1 MENG Yaqi2 BAO Yiqin3 WANG Zhu4 |
1.Department of Respiratory Medicine, Jianhu Hospital Affiliated to Nantong University, Jiangsu Province, Yancheng 224700, China;
2.Department of Respiratory and Critical Care Medicine, Jiangsu Provincial People’s Hospital, Jiangsu Province, Nanjing 210029, China;
3.Department of Respiratory and Critical Care Medicine, Wuhu Second People’s Hospital, Anhui Province, Wuhu 241000, China;
4.Department of Thoracic Surgery, Affiliated Hospital of Xuzhou Medical University, Jiangsu Province, Xuzhou 221000, China |
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Abstract Objective To investigate the value of serum and alveolar lavage fluid galactomannan (GM) test in the diagnosis of pulmonary aspergillosis. Methods From June 2015 to June 2019, 90 patients with suspected pulmonary aspergillosis treated in Jianhu Hospital Affiliated to Nantong University were selected as research subjects. Patients received a combination of serum and alveolar lavage fluid GM therapy. GM values of serum and alveolar lavage fluid of different patients were compared according to clinical diagnosis, and the ROC curve was used to analyze the diagnostic value of GM values of serum and alveolar lavage fluid in diagnosing pulmonary aspergillosis. Results Among 90 patients suspected of pulmonary aspergillosis, pulmonary aspergillosis was confirmed in 39 cases, pulmonary aspergillosis was suspected in 21 cases and non-pulmonary aspergillosis in 30 cases. The GM values of serum and alveolar lavage fluid in confirmed and suspected pulmonary aspergillus patients were higher than those in non-aspergillus patients (P < 0.05). The area under curve of ROC of GM value of serum and alveolar lavage fluid in diagnosing pulmonary aspergillosis were 0.794 and 0.870 respectively, the cut-off values were 0.43 and 0.88 respectively, the sensitivity were 74.00% and 82.00% respectively, the specificity were 75.00% and 100.00% respectively. By parallel test, the sensitivity and specificity of serum combined with alveolar lavage fluid GM value for diagnosis of aspergillus disease were 88.00% and 85.00%; by tandem test, the sensitivity and specificity of serum combined with alveolar lavage fluid GM for diagnosis of aspergillosis were 70.00% and 100.00%. Conclusion The GM test of serum and alveolar lavage fluid has a good application value in the diagnosis of pulmonary aspergillosis and is worth clinical use.
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