Lynch综合征相关结直肠癌患者TYMS基因多态性研究

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Abstract Objective To study the polymorphism of thymidylate synthase (TYMS) gene in patients with colorectal cancer associated with Lynch syndrome in Beijing area, and to analyze the relationship between TYMS gene polymorphism and the effect of 5-Fluorouracil chemotherapy by literature. Methods A total of 102 cases of colorectal cancer tissues were collected from patients who underwent surgery in four hospitals in Beijing from April 2015 to December 2016, including 61 males and 41 females. Immunohistochemistry and gene sequence detection methods were used to screen out Lynch syndrome patients, and then the polymorphisms of TYMS genes in these patients were identified by gene sequencing. Results Among 102 patients with colorectal cancer, there were 10 patients with Lynch syndrome. Among them, TYMS gene polymorphisms of 2R/2R and 3RC/3RC were four patients, while 2R/3RG, 3RC/3RG and 3RG/3RG were six patients. Among the high-expressing group, there were four males and two females; among the low-expressing group, there were one male and three females. Conclusion Most of the TYMS gene polymorphisms in patients with Lynch syndrome and colorectal cancer in Beijing area are 2R/3RG, 3RC/3RG or 3RG/3RG, which are related to the high expression of this gene, and the efficacy of Fluorouracil drugs is not good. The TYMS gene polymorphisms in patients with Lynch syndrome and colorectal cancer in Beijing area are 2R/3RG or 3RG/3RG, which are related to the high expression of this gene, and the efficacy of Fluorouracil drugs is not good.

Key words： Lynch syndrome Colorectal cancer Thymidylate synthase Fluorouracil

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	NIE Chen1 GAO Lei2 WANG Junyi3 LI Yueting1

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NIE Chen1 GAO Lei2 WANG Junyi3 LI Yueting1. Polymorphism of TYMS gene of patients with colorectal cancer associated with Lynch syndrome[J]. 中国医药导报, 2021, 18(11): 100-104.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I11/100

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