早发型重度子痫前期患者有无合并慢性高血压期待治疗的临床对比分析

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Abstract Objective To analyze the differences of expected treatment time, influencing factors and maternal and infant outcomes between patients with chronic hypertension complicated with early onset severe preeclampsia (CHEOSP) and patients with early onset severe preeclampsia (EOSP). Methods Four hundred and ninety-three cases of singleton EOSP patients admitted to Maternal and Child Health Hospital of Anhui Medical University from January 2018 to January 2020 were selected as research objects. They were divided into CHEOSP group (group A) with 98 cases and EOSP group (group B) with 395 cases according to whether complicated with chronic hypertension. The general situation, expected treatment time, influencing factors and maternal and infant outcomes of two groups were compared. Results The proportion of multipara, systolic blood pressure and diastolic blood pressure in group A were higher than those in group B, and serum uric acid in group A was lower than that in group B, the differences were statistically significant (P < 0.05). Gestational age less than 28 weeks, the gestational age and delivery gestational age of group A were shorter than those of group B, and expected treatment time of group A was longer than that of group B, the differences were statistically significant (P < 0.05). Gestational age from 28 to 32 weeks, expected treatment time and delivery gestational age of group A were longer than those of group B, the differences were statistically significant (P < 0.05). Gestational age from 32 to 33+6 weeks, the gestational age of group A was shorter than that of group B, and expected treatment time and delivery gestational age of group A were longer than those of group B (P < 0.05). The incidence rate of hypoproteinemia, hydrothorax and ascites in group A were lower than those in group B, and the incidence rate of fetal growth restriction and fetal distress in group A were higher than those in group B (P < 0.05). Pearson product moment correlation showed that expected treatment time of group A and B was positively correlated with plasma albumin level (r = 0.800, 0.780, P < 0.01) and negatively correlated with 24 hours urinary protein level (r = -0.398, -0.433, P < 0.01). Conclusion Patients with CHEOSP have longer expected treatment time than those with EOSP alone, there is no serious complication on the basis of the disease itself. However, in the course of expected treatment, we should pay attention to the level of plasma albumin and the occurrence of complications such as pleural effusion and ascites. It may cause the termination of pregnancy.

Key words： Simple early onset severe preeclampsia Chronic hypertension Early onset severe preeclampsia Expected treatment time Influencing factors Maternal and infant outcome

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	LIU Min WANG Haixia CHEN Xianxia

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LIU Min WANG Haixia CHEN Xianxia. Clinical comparative analysis of patients with early onset severe preeclampsia with or without chronic hypertension expectant treatment[J]. 中国医药导报, 2021, 18(11): 91-95.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I11/91

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