非小细胞肺癌中转录因子SOX2的表达及其临床意义

Abstract
Figure/Table
References (25)
Related Citation (15)

Download: PDF (603 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the expression between transcription factor SOX2 in non-small cell lung cancer (NSCLC) and association clinicopathological characteristics and prognosis. Methods From January 2017 to May 2019, 74 NSCLC specimens were collected from the First Affiliated Hospital of Chengdu Medical College and confirmed by the pathology department. Immunohistochemistry was used to detect the expression of SOX2 in NSCLC tissues and paracancerous tissues, and its clinicopathological characteristics and the prognosis of patients were analyzed. Results The positive rate of SOX2 in NSCLC tissues was higher than that in paracarcinoma tissues, and the difference was highly statistically significant (P < 0.01). There were statistically significant differences in SOX2 positive rate among different histological types, lymph node metastasis and clinical stages (P < 0.05 or P < 0.01). This study was followed up from April 2017，and follow-up was conducted up to April 2020. NSCLC patients with SOX2 positive expression lived longer than that with SOX2 negative expression, and the difference was highly statistically significant (P < 0.01). SOX2 positive expression and lymph node metastasis were independent influence factors in prognosis of patients with NSCLC (RR > 1, P < 0.05). Conclusion SOX2 expression in NSCLC tissues is related to histological type and clinical stage, which can be used as a potential biomarker for diagnosis and prognosis of NSCLC.

Key words： Non-small cell lung cancer SOX2 Clinicopathological characteristics Prognosis

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	YANG Fang1 LI Pengcheng1 LIU Wei1 ZHOU Yan’gang1 WANG Xiaoyan2 REN Tao1

Cite this article:

YANG Fang1 LI Pengcheng1 LIU Wei1 ZHOU Yan’gang1 WANG Xiaoyan2 REN Tao1. Expression of transcription factor SOX2 in non-small cell lung cancer and its significance[J]. 中国医药导报, 2021, 18(11): 29-32.

URL:

https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I11/29

[1] Siegel RL，Miller KD，Jemal A. Cancer statistics，2020 [J]. CA Cancer J Clin，2020，70（1）：7-30.
[2] Torre LA，Siegel RL，Jemal A. Lung Cancer Statistics [J]. Adv Exp Med Biol，2016，893：1-19.
[3] Wen Y，Hou Y，Huang Z，et al. SOX2 is required to maintain cancer stem cells in ovarian cancer [J]. Cancer Sci，2017，108（4）：719-731.
[4] Liu K，Xie F，Gao A，et al. SOX2 regulates multiple malignant processes of breast cancer development through the SOX2/miR-181a-5p，miR-30e-5p/TUSC3 axis [J]. Mol Cancer，2017，16（1）：62.
[5] Lee SH，Oh SY，Do SI，et al. SOX2 regulates self-renewal and tumorigenicity of stem-like cells of head and neck squamous cell carcinoma [J]. Br J Cancer，2014，111（11）：2122-2130.
[6] Que J，Luo X，Schwartz RJ，et al. Multiple roles for Sox2 in the developing and adult mouse trachea [J]. Development，2009，136（11）：1899-1907.
[7] Schaal CM，Bora-Singhal N，Kumar DM，et al. Regulation of Sox2 and stemness by nicotine and electronic-cigarettes in non-small cell lung cancer [J]. Mol Cancer，2018，17（1）：149.
[8] Sholl LM，Barletta JA，Yeap BY，et al. SOX2 protein expression is an independent poor prognostic indicator in stage Ⅰ lung adenocarcinoma [J]. Am J Surg Pathol，2010， 34（8）：1193-1198.
[9] Sasaki H，Yokota K，Hikosaka Y，et al. Increased Sox2 copy number in lung squamous cell carcinomas [J]. Exp Ther Med，2012，3（1）：44-48.
[10] Wilbertz T，Wagner P，Petersen K，et al. SOX2 gene am plification and protein overexpression are associated with better outcome in squamous cell lung cancer [J]. Mod Pathol，2011，24（7）：944-953.
[11] Ying J，Shi C，Li CS，et al. Expression and significance of SOX2 in non-small cell lung carcinoma [J]. Oncol Lett，2016，12（5）：3195-3198.
[12] Li Q，Liu F，Zhang Y，et al. Association of SOX2 and Nestin DNA amplification and protein expression with clinical features and overall survival in non-small cell lung cancer：A systematic review and meta-analysis [J]. Oncotarget，2016，7（23）：34520-34531.
[13] Velcheti V，Schalper K，Yao X，et al. High SOX2 levels predict better outcome in non-small cell lung carcinomas [J]. PLoS One，2013，8（4）：e61427.
[14] Chen SS，Li K，Wu J，et al. Stem signatures associated antibodies yield early diagnosis and precise prognosis predication of patients with non-small cell lung cancer [J]. J Cancer Res Clin Oncol，2021,147（1）：223-233.
[15] Bora-Singhal N，Mohankumar D，Saha B，et al. Novel HDAC11 inhibitors suppress lung adenocarcinoma stem cell self-renewal and overcome drug resistance by suppressing Sox2 [J]. Sci Rep，2020，10（1）：4722.
[16] Chen WW，Gong KK，Yang LJ，et al. Scutellariabarbata D. Don extraction selectively targets stemness-prone NSCLC cells by attenuating SOX2/SMO/GLI1 network loop [J]. J Ethnopharmacol，2020，265：113295.
[17] Yang YG，Koh YW，Sari IN，et al. Interferon-induced transmembrane protein 1-mediated EGFR/SOX2 signaling axis is essential for progression of non-small cell lung cancer [J]. Int J Cancer，2019，144（8）：2020-2032.
[18] Choe C，Kim H，Min S，et al. SOX2，a stemness gene，induces progression of NSCLC A549 cells toward anchorage-independent growth and chemoresistance to vinblastine [J]. Onco Targets Ther，2018，11：6197-6207.
[19] Hur JY，Kim HR，Lee JY，et al. CDK7 inhibition as a promising therapeutic strategy for lung squamous cell carcinomas with a SOX2 amplification [J]. Cell Oncol（Dordr），2019，42（4）：449-458.
[20] Yuan XW，Wang DM，Hu Y，et al. Hepatocyte nuclear factor 6 suppresses the migration and invasive growth of lung cancer cells through p53 and the inhibition of epithelial-mesenchymal transition [J]. J Biol Chem，2013， 288（43）：31206-31216.
[21] Wang RH，Zhu XJ，Wang Q，et al. The anti-tumor effect of taxifolin on lung cancer via suppressing stemness and epithelial-mesenchymal transition in vitro and oncogenesis in nude mice [J]. Ann Transl Med，2020，8（9）：590.
[22] Chang Z. Downregulation of SOX2 may be targeted by miR-590-5p and inhibits epithelial-to-mesenchymal transition in non-small-cell lung cancer [J]. Exp Ther Med，2019，18（2）：1189-1195.
[23] Zhang KW，Li Y，Qu LM，et al. Long noncoding RNA Sox2 overlapping transcript（SOX2OT）promotes non-small-cell lung cancer migration and invasion via sponging microRNA 132（miR-132）[J]. Onco Targets Ther，2018，11：5269-5278.
[24] Gao W，Qi CQ，Feng MG，et al. SOX2-induced upregulation of lncRNA LINC01561 promotes non-small-cell lung carcinoma progression by sponging miR-760 to modulate SHCBP1 expression [J]. J Cell Physiol，2020， 235（10）：6684-6696.
[25] Wang FF，Wang S，Xue WH，et al. microRNA-590 suppresses the tumorigenesis and invasiveness of non-small cell lung cancer cells by targeting ADAM9 [J]. Mol Cell Biochem，2016，423（1/2）：29-37.