脑脊液Aβ、tau蛋白诊断阿尔茨海默病的系统评价和meta分析

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Abstract Objective To evaluate the accuracy of β-amyloid protein 42 (Aβ42), total tau (t-tau) and phosphorylation tau (p-tau) proteins in cerebrospinal fluid in the diagnosis of Alzheimer’s disease (AD). Methods CNKI, WanFang, VIP, China Biology Medicine disc, PubMed, Embase, and Cochrane Library were searched for diagnostic tests of cerebrospinal fluid biomarkers in the diagnosis of AD, and the search time was from January 2000 to May 2020. According to the inclusion and exclusion criteria, the literatures were screened, the quality of the included literatures was evaluated, and the data were extracted for meta analysis using STATA15 software. Results A total of ten literatures were included. The results of meta-analysis showed that the sensitivity of cerebrospinal fluid Aβ42 in the diagnosis of AD was 0.85(95%CI [0.67, 0.94]), the specificity was 0.90(95%CI [0.83, 0.94]), the area under the summary receiver operating characteristic (SROC) curve (AUC) was 0.91(95%CI [0.89, 0.94]). The sensitivity of cerebrospinal fluid t-tau in the diagnosis of AD was 0.79(95%CI [ 0.65, 0.89]), the specificity was 0.83(95%CI [0.76, 0.89]), the AUC was 0.88(95%CI [0.85, 0.90]). The sensitivity of cerebrospinal fluid p-tau in the diagnosis of AD was 0.77(95%CI [0.69, 0.84]), the specificity was 0.82(95%CI [0.65, 0.91]), the AUC was 0.84(95%CI [0.80, 0.87]). Conclusion The accuracy of Aβ42, t-tau and p-tau in cerebrospinal fluid in the diagnosis of AD is relatively high. However, due to the limitation of the number of included studies and publication bias, more high-quality studies are needed to verify the results.

Key words： Alzheimer’s disease meta-analysis Cerebrospinal fluid β-amyloid protein tau protein

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	ZHOU Yingyi NI Jingnian WEI Mingqing XU Xiaoqing TIAN Jinzhou SHI Jing▲

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ZHOU Yingyi NI Jingnian WEI Mingqing XU Xiaoqing TIAN Jinzhou SHI Jing▲. Systematic review and meta-analysis of Aβ and tau protein in cerebrospinal fluid in the diagnosis of Alzheimer’s disease[J]. 中国医药导报, 2021, 18(11): 14-19.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I11/14

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