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| Effect of Chongcao Bushen Capsules in the treatment of diabetic nephropathy patients with deficiency of both qi and yin type |
| XIE Qiufang ZHANG Yitong LIANG Guiting DUAN Junhong WEI Xuan WANG Juan LIU Bo FAN Yuzhu |
| The First Department of Endocrinology, Shijiazhuang Hospital of Traditional Chinese Medicine, Hebei Province, Shijia-zhuang 050051, China |
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Abstract Objective To observe the effect of Chongcao Bushen Capsules on serum levels of transforming growth factor-β1 (TGF-β1), connective tissue growth factor (CTGF), monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-α (TNF-α), reactive oxygen species (ROS) and superoxide dismutase (SOD) in patients with diabetic nephropathy of qi and yin deficiency type. Methods Sixty patients with diabetic nephropathy in Department of Endocrinology and Nephrology of Shijiazhuang Hospital of Traditional Chinese Medicine from March 2018 to June 2019 were selected and divided into treatment group and control group according to random number table method, with 30 cases in each group. Treatment group was given Chongcao Bushen Capsules and conventional treatment, and control group was given Chongcao Bushen Capsules Simulant and conventional treatment. The course of treatment was 6 weeks. The serum levels of TGF-β1, CTGF, MCP-1, TNF-α, ROS and SOD were compared between two groups. Results After treatment, the levels of TGF-β1, CTGF, MCP-1 and TNF-α in two groups were lower than those before treatment, and those in treatment group were lower than those in control group, the differences were statistically significant (P < 0.05). After treatment, the level of ROS in two groups was lower than that before treatment, and the level of SOD was higher than that before treatment, and the level of ROS in treatment group was lower than that in control group, and the level of SOD was higher than that in control group, the differences were statistically significant (P < 0.05). Conclusion Chongcao Bushen Capsules can slow down the process of renal fibrosis in diabetic nephropathy patients, which may be related to regulating cytokines, inhibiting inflammatory response and oxidative stress. Chongcao Bushen Capsules is an effective drug for the treatment of diabetic nephropathy and the control of its progress.
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