骨折患者出院后下肢深静脉血栓复发特点及危险因素分析

Abstract
Figure/Table
References (26)
Related Citation (15)

Download: PDF (586 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate characteristics and risk factors of recurrence of lower extremity deep venous thrombosis (DVT) in patients with fracture after discharge. Methods Clinical data of 90 patients with primary lower extremity DVT admitted to Department of Orthopaedic Trauma in Honghui Hospital Affiliated to Xi’an Jiaotong University from April 2014 to August 2019 were retrospectively analyzed. According to the results of venous ultrasound, they were divided into recurrent thrombosis group (44 cases) and non recurrent thrombosis group (46 cases). Univariate analysis was used to screen the risk factors of recurrent DVT, and multivariate logistic regression analysis was used to determine the independent risk factors. Results Forty-four cases of DVT recurred, the incidence was 48.89%. There were significant differences in age, gender, primary thrombus side, check hemoglobin and check D-dimer levels between recurrent thrombosis group and non recurrent thrombosis group (P < 0.05). Multivariate logistic regression analysis showed that age (OR = 1.082, 95%CI: 1.035-1.131), primary bilateral thrombosis (OR = 5.946, 95%CI: 1.034-34.181) and high check D-dimer level (OR = 2.059, 95%CI: 1.209-3.508) were independent risk factors for recurrent DVT (P < 0.05). Conclusion The recurrence rate of DVT with fracture patients after discharge is higher, but the distal thrombus is predominant. Elderly, primary bilateral thrombosis and high check D-dimer should be alert of recurrence of DVT after discharge.

Key words： Fracture Deep vein thrombosis with lower limbs Risk factors Recurrence

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	CAI Mingjian1 WANG Hu2 SHANG Kun2 ZHUANG Yan2 TIAN Ding2 ZHANG Kun2

Cite this article:

CAI Mingjian1 WANG Hu2 SHANG Kun2 ZHUANG Yan2 TIAN Ding2 ZHANG Kun2. Characteristics and risk factors of recurrence of lower extremity deep venous thrombosis in patients with fracture after discharge[J]. 中国医药导报, 2021, 18(8): 122-125.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2021/V18/I8/122

[1] Stewart LK，Kline JA. Metabolic syndrome increases risk of venous thromboembolism recurrence after acute deep vein thrombosis [J]. Blood Adv，2020，4（1）：127-135.
[2] Kyrle PA，Kammer M，Eischer L，et al. The long-term recurrence risk of patients with unprovoked venous thromboembolism：an observational cohort study [J]. J Thromb Haemost，2016，14（12）：2402-2409.
[3] 王亚馨，肖亚娟，李雪，等.创伤骨折患者术中导致DVT风险增高的危险因素分析[J].实用骨科杂志，2020，26（3）：219-222.
[4] 罗德军，周贵，李水燕，等.骨科患者深静脉血栓形成的影响因素分析[J].检验医学与临床，2020，17（9）：1221-1224.
[5] Maufus M，Elias A，Barrellier MT，et al. Diagnosis of deep vein thrombosis recurrence：ultrasound criteria [J]. Thromb Res，2018，161（1）：78-83.
[6] 潘元美，曹雯炜，秦洁行，等.血栓形成的抗栓治疗和预防，第9版：美国胸科医师学院循证的临床实践指南[J].神经病学与神经康复学杂志，2012，9（1）：43-64.
[7] Gibietis V，Kigitovica D，Strautmane S，et al. Venous thromboembolism recurrence in latvian population：single university hospital data [J]. Medicina（Kaunas），2019，55（9）：510.
[8] Asim M，Al-Thani H，El-Menyar A. Recurrent deep vein thrombosis after the first venous thromboembolism event：a single-institution experience [J]. Med Sci Monit，2017， 23：2391-2399.
[9] 丛雨轩，王鹏飞，张堃，等.下肢骨折患者围手术期DVT发生的时间规律[J].中国骨与关节损伤杂志，2018，33（12）：1318-1319.
[10] 景阳，丁萌，付久园，等.介入技术治疗下肢手术后深静脉血栓形成的效果与分析[J].河北医学，2019，25（6）：1006-1010.
[11] Ren W，Li Z，Fu Z，et al. Analysis of risk factors for recurrence of deep venous thrombosis in lower extremities [J]. Med Sci Monit，2014，20：199-204.
[12] Baglin T，Douketis J，Tosetto A，et al. Does the clinical presentation and extent of venous thrombosis predict likelihood and type of recurrence? A patient-level meta-analysis [J]. J Thromb Haemost，2010，8（11）：2436-2442.
[13] Seinturier C，Bosson JL，Colonna M，et al. Site and clinical outcome of deep vein thrombosis of the lower limbs：an epidemiological study [J]. J Thromb Haemost，2005，3（7）：1362-1367.
[14] Tosetto A，Testa S，Martinelli I，et al. External validation of the DASH prediction rule：a retrospective cohort study [J]. J Thromb Haemost，2017，15（10）：1963-1970.
[15] Galanaud JP，Sevestre MA，Genty C，et al. Incidence and predictors of venous thromboembolism recurrence after a first isolated distal deep vein thrombosis [J]. J Thromb Haemost，2014，12（4）：436-443.
[16] Eischer L，Eichinger S，Kyrle PA. Age at first venous thromboembolism and risk of recurrence：a prospective cohort study [J]. Medicine（Baltimore），2009，88（6）：366-370.
[17] Wang J，Tacey M，Ho P. Retrospective review of D-dimer testing for venous thrombosis recurrence risk stratification：is this a useful test in the real world ？[J]. J Thromb Thrombolysis，2020，49（4）：562-571.
[18] Cosmi B，Legnani C，Cini M，et al. D-dimer and residual vein obstruction as risk factors for recurrence during and after anticoagulation withdrawal in patients with a first episode of provoked deep-vein thrombosis [J]. Thromb Haemost，2011，105（5）：837-845.
[19] Bjori E，Johnsen HS，Hansen JB，et al. D-dimer at venous thrombosis diagnosis is associated with risk of recurrence [J]. J Thromb Haemost，2017，15（5）：917-924.
[20] El-Menyar A，Asim M，Jabbour G，et al. Clinical implications of the anatomical variation of deep venous thrombosis [J]. Phlebology，2018，33（2）：97-106.
[21] Palareti G. Recurrent venous thromboembolism：what is the risk and how to prevent it？[J]. Scientifica（Cairo），2012，2012：391734.
[22] Nagler M，Ten CH，Prins MH，et al. Risk factors for recurrence in deep vein thrombosis patients following a tailored anticoagulant treatment incorporating residual vein obstruction [J]. Res Pract Thromb Haemost，2018，2（2）：299-309.
[23] Trinchero A，Scheres L，Prochaska JH，et al. Sex-specific differences in the distal versus proximal presenting location of acute deep vein thrombosis [J]. Thromb Res，2018， 172（12）：74-79.
[24] Blanco-Molina A，Enea I，Gadelha T，et al. Sex differences in patients receiving anticoagulant therapy for venous thromboembolism [J]. Medicine（Baltimore），2014， 93（17）：309-317.
[25] Faqah A，Sheikh H，Bakar MA，et al. Comparative analysis of enoxaparin versus rivaroxaban in the treatment of cancer associated venous thromboembolism：experience from a tertiary care cancer centre [J]. Thromb J，2020，18（1）：1-6.
[26] Brownson KE，Brahmandam A，Huynh N，et al. Characteristics of provoked deep venous thrombosis in a tertiary care center [J]. J Vasc Surg Venous Lymphat Disord，2017，5（4）：477-484.