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| Analysis on risk factors associated with death in patients with pulmonary carbapenem-resistant Klebsiella pneumoniae infection / colonization |
| TIAN Lili1 WANG Shanshan2 ZHAO Jianping3 ZHANG Yemao4▲ |
1.Department of Care, Inner Mongolia People’s Hospital, Inner Mongolia Autonomous Region, Hohhot 010010, China;
2.Inner Mongolia Clinical Medical College, Inner Mongolia Medical University, Inner Mongolia Autonomous Region, Hohhot 010010, China;
3.Department of Clinical Laboratory, Inner Mongolia People’s Hospital, Inner Mongolia Autonomous Region, Hohhot 010010, China;
4.Department of Infection, the Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia Autonomous Region, Hohhot 010050, China |
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Abstract Objective To analyze the risk factors associated with death in patients with pulmonary infection / colonization of carbapenem-resistant Klebsiella pneumoniae (CRKP). Methods A total of 190 inpatients with CRKP cultured from respiratory tract specimens in Inner Mongolia People’s Hospital from January 2017 to June 2019 were collected for general data analysis and single (multiple) logistic regression analysis of mortality. Results The results of single logistic regression analysis showed that 15 other factors were correlated with death of patients with pulmonary CRKP infection /colonization, except for complications of hypertension, organ injury ≥ 3 sites on admission and the use of aminoglycoside antibiotics, with statistical significance (all P < 0.05). Multivariate logistic regression analysis showed that age ≥65 years (OR = 3.578, 95%CI [1.028-12.451], P = 0.034), male (OR = 7.030, 95%CI [1.164-42.463], P = 0.045), with diabetes (OR = 12.888, 95%CI [1.967-84.421], P = 0.008), use of mechanical ventilation (OR = 14.967, 95%CI [2.708-82.724], P = 0.002), history of surgical (OR = 28.026, 95%CI[4.964-158.237], P ＜ 0.001) and use of penicillin (OR = 80.626, 95%CI [8.263-786.737], P ＜ 0.001), cephalosporins (OR = 25.757, 95%CI [1.149-577.407], P = 0.041) were independent risk factors for death in patients with pulmonary infection/colonization of CRKP. Conclusion According to the independent risk factor analysis of CRKP infection, some invasive procedures should be avoided as far as possible in clinical practice, antimicrobial agents should be used rationally, management of high-risk population should be strengthened, and the occurrence of CRKP infection should be reduced and prevented.
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