机械取栓联合rt-PA静脉溶栓对大面积脑梗死神经功能及hs-CRP、Lp-PLA2水平的影响

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Abstract Objective To explore the effect of mechanical thrombus removal combined with recombinant tissue-type plasminogen activator (rt-PA) intravenous thrombolysis on nerve function and the levels of high-sensitivity C-reactive protein (hs-CRP) and lipoprotein-related phospholipase A2 (Lp-PLA2) in massive cerebral infarction. Methods The clinical data of 80 patients with massive cerebral infarction admitted to Lu’an People’s Hospital, Anhui Province from January 2018 to July 2020 were retrospectively analyzed, they were divided into observation group and control group according to different treatment methods, with 40 cases in each group. The control group was given rt-PA intravenous thrombolytic therapy, and the observation group was combined with mechanical thrombectomy on the basis of the control group. After three months of treatment, the clinical efficacy, the scores of National Institutes of Health stroke scale (NIHSS), modified Rankin scale (mRS), activity of daily living (ADL), levels of hs-CRP and Lp-PLA2 in the two groups were compared. And the adverse reactions of the two groups were compared. Results After treatment, the total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). After treatment, the NIHSS and mRS scores, the levels of hs-CRP and Lp-PLA2 of the two groups were lower than those before the treatment, and the ADL score was higher than that before the treatment, and the differences were statistically significant (all P ＜ 0.05). NIHSS and mRS scores, the levels of hs-CRP and Lp-PLA2 of the observation group were lower than those in the control group, and the ADL score was higher than that in the control group, the differences were statistically significant (P ＜ 0.05). The incidence of adverse reactions in observation group was lower than that in control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The mechanical thrombectomy combined with rt-PA intravenous thrombolysis has a significant clinical effect in the treatment of massive cerebral infarction.

Key words： Massive cerebral infarction Mechanical thrombus removal Recombinant tissue-type plasminogen activator Neurological function High-sensitivity C-reactive protein Lipoprotein-related phospholipase A2

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	CONG Guangyan ZHANG Yong YAN Xingya

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CONG Guangyan ZHANG Yong YAN Xingya. Effect of mechanical thrombus removal combined with rt-PA intravenous thrombolysis on nerve function and the levels of hs-CRP and Lp-PLA2 in massive cerebral infarction[J]. 中国医药导报, 2021, 18(8): 78-81.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2021/V18/I8/78

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