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| Study on risk factors of cognitive disorder in patients with mild acute ischemic stroke |
| ZHAO Shijiao1 MEN Hui1 WANG Ying1 LI Shixin1 YAN Yu1 DAI Lingling1 CHEN Baoxin2 JIN Xianglan2▲ |
1.The Second Clinical School, Beijing University of Chinese Medicine, Beijing 100029, China;
2.the Second Department of Encephalopathy, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China |
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Abstract Objective To explore risk factors of cognitive disorder in patients with mild acute ischemic stroke. Methods A total of 84 patients with mild acute ischemic stroke admitted to the Department of Encephalopathy, Dongfang Hospital, Beijing University of Chinese Medicine from January 2015 to September 2018 were selected as subjects. Their general clinical data and biochemical indicators were collected. On the 10th to 14th day after stroke, they were evaluated by the Montreal cognitive assessment (MOCA) scale. According to the evaluation results, the patients were divided into the non-cognitive disorder group (30 cases) (MOCA scores≥26 points) and the cognitive disorder group (54 cases) (MOCA scores＜26 points). The two groups were statistically analyzed and discussed. Results The age and serum homocysteine (Hcy) level of the cognitive disorder group were higher than those of the non-cognitive disorder group, and the standard of culture was lower than that of the non-cognitive disorder group, the differences were statistically significant (all P ＜ 0.05). There were no significant differences between the two groups in gender, previous history, smoking, alcohol consumption, white matter demyelination, infarct location and number, total cholesterol, low density lipoprotein, high density lipoprotein, triglyceride, fasting blood glucose, etc. (P ＞ 0.05). Multivariate logistic regression analysis showed that increased age (OR = 1.071, 95%CI [1.010-1.137], P = 0.022) and serum Hcy level (OR = 1.102, 95%CI [1.002-1.213], P = 0.046) were the independent risk factors for cognitive disorder in patients with mild acute ischemic stroke (P ＜ 0.05). While the highe standard of culture (OR = 0.487, 95%CI [0.268-0.884], P = 0.018) was its independent protective factor (P ＜ 0.05). Conclusion Advanced age, low standavd of culture level and elevated serum Hcy level are closely related to cognitive disorder in patients with mild acute ischemic stroke. As a modifiable physical and chemical factor, monitoring and controlling serum Hcy level in the early acute phase may be helpful to prevent the occurrence of cognitive disorder after stroke.
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