脊柱椎间融合动物模型研究进展

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Abstract Spinal interbody fusion is a routine technique for the treatment of spinal trauma, spinal tumor, degenerative diseases and spinal deformity. Spinal interbody fusion enables solid bony fixation of the fused bone graft segments, and it can also open and maintain the normal height of interbody fusion. However, spinal fusion failure is a problem that spinal surgeons must face in clinical work. A large number of clinical observations have shown that spinal fusion currently has a 10% to 15% non-fusion rate with internal fixation. Many researchers have investigated the effects of new surgical procedures, fusion devices, and bone graft materials on fusion rate in animals. However, there are many kinds of animals with different characteristics. Large animals are better able to simulate the biomechanics of bone graft materials or spinal instruments in the human body, while small animals have more advantages in the study of conceptual strategies. The selection of suitable animal models is the key to the success of experiments, but there is no unified standard for animal selection at present. This paper reviews the characteristics of different animal models of spinal intervertebral vertebrae, in order to provide a theoretical basis for animal research.

Key words： Spine Spinal interbody fusion Fusion rate Characteristics of animal spine Animal model

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	TANG Xiaoyong HE Bin

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TANG Xiaoyong HE Bin. Research progress of animal models of spinal interbody fusion[J]. 中国医药导报, 2021, 18(8): 38-41.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2021/V18/I8/38

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