新生儿缺氧缺血性脑病血清HMGB1、脂蛋白a水平变化及临床意义

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Abstract Objective To investigate of levels changes of serum high mobility group box-1 protein (HMGB1) and lipoprotein a in newborns with hypoxic ischemic encephalopathy and its clinical significances. Methods A total of 105 newborns with hypoxic ischemic encephalopathy which diagnosed and treated in Maternity and Child Care Center of Qinhuangdao, Hebei Province (referred to as “our hospital” for short) from January 2018 to March 2020 were selected as the observation group. According to the grading standard, they were further divided into mild group (57 cases), moderate group (33 cases) and severe group (15 cases). Fifty-three healthy newborns born in the department of obstetrics and gynecology of our hospital during the same period were selected as the control group. Serum levels of HMGB1, lipoprotein a and neonatal behavioral neurological assessment (NBNA) scores were compared in different group. The correlation between serum levels of HMGB1, lipoprotein a and NBNA score was analyzed. Receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of serum HMGB1 and lipoprotein a levels in newborns with hypoxic ischemic encephalopathy. Results The levels of serum HMGB1 and lipoprotein a in the observation group were significantly higher than those in the control group, and the differences were statistically significant (all P ＜ 0.05). The levels of serum HMGB1 and lipoprotein a in the severe group were higher than those in the moderate and mild groups, while the NBNA score was lower than that in the moderate group and mild group, with statistically significant differences (all P ＜ 0.05). The serum HMGB1 and lipoprotein a levels of the moderate group were higher than those in the mild group, while the NBNA score was lower than that in the mild group, with statistically significant differences (all P ＜ 0.05). Serum levels of HMGB1 (r = -0.9123，P ＜ 0.05) and lipoprotein a (r = -0.9045，P ＜ 0.05) were both negatively correlated with NBNA score. ROC curve analysis results showed that the combined detection of serum HMGB1 and lipoprotein a was more valuable in the diagnosis of newborns with hypoxic ischemic encephalopathy than the individual detection. Conclusion The serum levels of HMGB1 and lipoprotein a of newborns with hypoxic ischemic encephalopathy are increased and correlated with the severity of the disease, which can be used as molecular markers for the diagnosis of hypoxic ischemic encephalopathy.

Key words： Hypoxic ischemic encephalopathy High mobility group box-1 protein Lipoprotein a Diagnosis

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	JIANG Shuping ZHU Hongbin LIU Fang CAI Haiyan FENG Ningning YAN Aixia

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JIANG Shuping ZHU Hongbin LIU Fang CAI Haiyan FENG Ningning YAN Aixia. Changes of levels of serum HMGB1 and lipoprotein a in newborns with hypoxic ischemic encephalopathy and its clinical significances[J]. 中国医药导报, 2021, 18(8): 25-28,49.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2021/V18/I8/25

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