尿免疫球蛋白G与急性ST段抬高型心肌梗死患者院内全因死亡的关系研究

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Abstract Objective To explore the relationship between urine immunoglobulin G (UIgG) and in-hospital death in patients with acute ST elevation myocardial infarction (STEMI). Methods A total of 1854 STEMI patients admitted to Beijing Friendship Hospital from 2013 to 2019 were retrospectively included, UIgG and other baseline data were collected. According to the UIgG tertiles, they were divided into three groups, including 668 cases in the low UIgG group, 570 cases in the medium UIgG group, and 616 cases in the high UIgG group. The primary clinical endpoint was all-cause death in the hospital, and the secondary endpoint was cardiovascular death and adverse cardiovascular events. The differences in the clinical indicators of the three groups were compared, while the related factors of hospital death were analyzed, and the ROC curve was draw. Results The three groups of age, male ratio, history of hypertension, white blood cells, blood creatinine, total bilirubin, high-sensitivity C-reactive protein, and glycosylated hemoglobin were compared, and the differences were statistically significant (P ＜ 0.05). The above indicators in the high UIgG group were higher than those in the low UIgG group, and the difference was statistically significant (P ＜ 0.05). The three groups of hospital death, cardiogenic death, MACE ratio, N-terminal pro-brain natriuretic peptide, creatine kinase isoenzyme-MB, cardiac troponin, and left ventricular ejection fraction were compared, and the differences were statistically significant (P ＜ 0.05). The peaks of NT-proBNP, CK-MB, and cTnI in the high UIgG group were higher than those in the low UIgG group, while LVEF was lower than that in the low UIgG group, and the differences were highly statistically significant (P ＜ 0.01). The incidence of in-hospital death, cardiogenic death and MACE in the high UIgG group were higher than those in the low UIgG group, and the differences were highly statistically significant (P ＜ 0.01). UIgG was an independent risk factor for in-hospital death in STEMI patients (OR = 1.042, 95%CI: 1.002-1.083, P = 0.042). When UIgG was the cut point of 2.09 mg/dL, the AUC was 0.75 (95%CI: 0.67-0.82, P ＜ 0.01), the sensitivity was 67.4%, and the specificity was 76.5%. Conclusion UIgG is an independent risk factor associated with hospital death in STEMI patients.

Key words： ST elevated myocardial infarction Hospital mortality Urinary immunoglobulin G Prognosis

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	CUI Hehe YAO Daokuo ZHOU Li DING Xiaosong BAI Yutian LI Hongwei CHEN Hui

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CUI Hehe YAO Daokuo ZHOU Li DING Xiaosong BAI Yutian LI Hongwei CHEN Hui. Relationship between urinary immunoglobulin G and all-cause mortality in patients with acute ST-segment elevation myocardial infarction[J]. 中国医药导报, 2021, 18(8): 20-24.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2021/V18/I8/20

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