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| Analgesic effect of multimodal analgesia technique in transverse incision cesarean section of singleton pregnancy |
| LI Jia1 SHEN Mingkun2 |
1.Department of Anesthesiology, the Third People’s Hospital of Huishan District of Wuxi City, Jiangsu Province, Wuxi 214000, China;
2.Department of Anesthesiology, Wuxi Maternal and Child Health Care Hospital, Jiangsu Province, Wuxi 214000, China |
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Abstract Objective To study the analgesic effect of multimodal analgesia (MMA) technique in transverse incision cesarean section of singleton pregnancy. Methods Ninety-four patients with selective transverse incision cesarean section of singleton pregnancy admitted to WuXi Maternal and Child Health Care Hospital from October 2016 to October 2018 were divided into control group and observation group by random number table method, with 47 cases in each group. Control group was given traditional mode analgesia, observation group was given MMA. The visual analogue scales (VAS) at 2, 12 h and 24 h after operation were observed in two groups. The levels of β-endorphin (β-EP) and neuropeptide Y (NPY) were measured at before and 24 h after operation in two groups. The initial lactation time and satisfaction scores were compared in two groups, and the incidence of adverse reactions in two groups was recorded. Results There were significant differences in VAS of both resting-pain and exercise-pain between groups, time point comparison and interaction between the two groups (all P ＜ 0.05). Further intra-group comparison showed that the VAS of resting-pain and exercise-pain at 12 h after operation in two groups were significantly higher than those of at 2 h after operation, and the VAS of resting-pain and exercise-pain at 24 h after operation were significantly lower than those of at 2 h after operation and the differences were statistically significant (all P ＜ 0.05). Comparison between groups showed that the VAS of resting-pain and exercise-pain in the observation group were lower than those in the control group at 12 h and 24 h after operation, and the differences were statistically significant (all P ＜ 0.05). The initial lactation time in observation group was shorter than that in control group, and the satisfaction score was higher than that in control group (all P ＜ 0.05). Twenty-four hours after operation, the levels of β-EP and NPY in both groups were higher than those before operation, and the observation group were lower than the control group, and the differences were statistically significant (all P ＜ 0.05). The adverse reaction rate in the observation group was lower than that in the control group (P ＜ 0.05). Conclusion The MMA technique is safe and effective in cesarean section with transverse incision of singleton pregnancy.
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