基于网络药理学角度探讨银芪软膏对糖尿病足溃疡的干预机制

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Abstract Objective To explore the effective ingredients and intervention mechanism of Yinqi Ointment in the treatment of diabetic foot ulcer, and to provide new ideas and methods for the development of new drugs. Methods The key target network of Yinqi Ointment in the treatment of diabetic foot ulcer was constructed with chemical composition data of Yinqi Ointment, candidate disease targets for diabetic foot ulcer, protein-protein interaction between information between potential targets of Yinqi Ointment and diabetic foot ulcer disease targets which were obtained from integrative pharmacology-based research platform of traditional Chinese medicine. Then the key targets and pathways of Yinqi Ointment in the treatment of diabetic foot ulcer were found by using the results of gene ontology database and enrichment analysis. Results Four key drug targets of Yinqi Ointment were found and the most key target for Yinqi Ointment in the treatment of diabetic foot ulcer might be HSP90AA1. The synthesis, recycling, salvage and regulation of tetrahydrobiopterin (BH4), endothelial nitric oxide synthase activation, and vascular endothelial cell growth factor receptor 2 mediated vascular permeability were the most important pathways for the treatment of diabetic foot ulcer. Conclusion Although this study provides a basis for the further study of Yinqi Ointment and its Chinese herbal ingredients, it is only based on the prediction of the integrated pharmacology platform. The specific mechanism and the development of new drugs need to be supported by specific laboratory research.

Key words： Network pharmacology Yinqi Ointment Diabetic foot ulcer Mechanism

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	CHEN Runming DU Yuqing LI Youshan DONG Xueyu AN Qi XIE Cunxiang

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CHEN Runming DU Yuqing LI Youshan DONG Xueyu AN Qi XIE Cunxiang. Discussing the intervention mechanism of Yinqi Ointment on diabetic foot ulcer from the perspective of network pharmacology[J]. 中国医药导报, 2021, 18(7): 4-8,17.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2021/V18/I7/4

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