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| Research progress of Janus kinase inhibitors in the treatment of atopic dermatitis |
| YANG Liting WU Liming |
| Department of Dermatology, Nanjing Medical University, Affiliated Hangzhou First People’s Hospital, Zhejiang Province, Hangzhou 310006, China |
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Abstract Atopic dermatitis is a chronic inflammatory skin disease related to impaired epidermal barrier function and immune function imbalance. Its pathogenesis is closely related to the Janus kinase (JAK)-signal transduction and activator of transcription (STAT) signaling pathway. According to blocking the JAK-STAT signaling pathway mediated by interleukin (IL)-4, IL-13, IL-31 and other related cytokines, it affects the expression of downstream genes, thereby treating atopic dermatitis. This article reviews recent studies on the involvement of JAK-STAT signaling pathway in the pathogenesis of atopic dermatitis and the application of JAK inhibitors in atopic dermatitis.
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