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| Correlative study about sleep disorders of elderly patients with dementia |
| HUANG Jingjing XU Zhen QU Chen FENG Meijiang |
| Department of Geriatrics, the Second Affiliated Hospital of Nanjing Medical University, Jiangsu Province, Nanjing 210011, China |
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Abstract Objective To explore the correlation between sleep disorders of elderly patients and different levels of dementia. Methods From January 2014 to December 2015, a total of 176 elderly patients were selected in the sleep disorder clinic, the Second Affiliated Hospital of Nanjing Medical University as research objects and divided into the group 1 control (scores≥27, n = 45), group 1 mild (scores 19-26, n = 42), group 1 moderate (scores 10-18, n = 44) and group 1 severe (scores≤9, n = 45) according to the mini-mental state examination (MMSE). To eliminate the effect of elderly common diseases to dementia, the patients without the elderly common diseases were also divided into 4 groups：group 2 control (scores ≥27, n = 22), group 2 mild (scores 19-26, n = 21), group 2 moderate (scores ≥10-18, n = 23) and group 2 severe (scores ≤9, n = 21). The relationship between different levels of dementia and sleep structure was analyzed by overnight polysomnography (PSG) monitoring. Results rapid eye movement (REM), sleep efficiency(SE) of the group 1 mild were lower than those of the group 1 control,with statistically significant difference(P ＜ 0.05);SL(sleep latency) in the group 1 moderate was higher than those of the group 1 control, REM, SE in the group 1 moderate were lower than those of group 1 control,while SL was higher and SE was lower in the group 1 moderate than those of group 1 mild,with statistically significant differences(P ＜ 0.05); SL in group 1 severe was higher than those in group 1 control and group 1 mild, REM and SE in group 1 severe were significantly lower than those in group 1 control, group 1 mild and group 1 moderate, with statistically significant differences (P ＜ 0.05). REM and SE in group 2 mild were lower than those of group 2 control, with statistically significant differences (P ＜ 0.05); SL in group 2 moderate was higher than that in group 2 control, REM, total sleep time(TST) and SE in group 2 moderate were lower than those in group 2 control, SL was higher than that in group 2 mild, TST, SE were lower than those in group 2 mild, with statistically significant differences (P ＜ 0.05); SL in group 2 severe was higher than those in group 2 control and group 2 mild, REM, TST and SE in group 2 severe were significantly lower than those in group 2 control and group 2 mild, REM, SE were lower than group 2 moderate, with statistically significant differences(P ＜ 0.05). Conclusion The elderly patients with dementia have a significant decline in sleep quality. The more severe the dementia was, the worse the quality of sleep was. PSG monitoring is useful for patients no matter whether they have common diseases of the elderly or not. Therefore, PSG can be used as a supplementary indicator to assess the process and development of dementia.
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