胆道系统印戒细胞癌的临床病理特点及预后状况分析

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Abstract Objective To analyze the clinical pathological characteristics and prognosis of signet-ring cell carcinoma of biliary tract. Methods The clinical pathological data of 11 patients who were diagnosed as signet-ring cell carcinoma of biliary tract in Wuxi People's Hospital Affiliated to Nanjing Medical University from May 2007 to October 2016 was analyzed retrospectively, and the prognosis conditions of patients were followed up until December 26, 2016. Results Among 11 cases of patients with signet-ring cell carcinoma of biliary tract, there were 5 cases of male and 6 cases of female, the male to female ratio was 1∶1.2, the episode age was 43-78 years old, with an average of 62.4 years old, the main clinical symptoms were discomfort of right upper quadrant [9 cases (81.8%)] and jaundice [7 cases (63.6%)]. In the pathological location, there were 7 cases (63.6%) in gall bladder. There were 8 cases (72.7%) combined with cholecystitis, 7 cases (63.6%) combined with biliary calculus. In the pathological patterns, adenocarcinoma combined with signet-ring cell carcinoma was more [9 cases (81.8%)], single signet-ring cell carcinoma was less [2 cases (18.2%)]. There were 6 cases (54.5%) of low-differentiated and 8 cases (72.7%) with distant metastasis. All 11 cases took operative treatment, 2 cases received chemotherapy. At the end of the follow-up period, among the patients with definite prognosis, 6 cases (75%) were dead, 2 cases (25%) were survived. The overall survival time was 0-56 months, with an average of 19.3 months. Conclusion Signet-ring cell carcinoma of biliary tract is rare in clinic, which is commonly started from the middle aged and elderly population, the main pathological location is gallbladder, the main clinical symptoms are discomfort of right upper quadrant and jaundice, combining with cholecystitis and biliary calculus may be the related factors of morbidity, the main pathological pattern is adenocarcinoma combined with signet-ring cell carcinoma, the malignant grade is high, the patients are often in the middle and advanced stage when they are diagnosed, the operation is the main therapeutic method, the benefit of chemoradiotherapy still needs further research, the overall prognosis is bad.

Key words： Biliary tract Signet-ring cell carcinoma Pathology Prognosis

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	XIA Dandan WANG Runjie LIU Chaoying▲

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XIA Dandan WANG Runjie LIU Chaoying▲. Analysis on clinical pathological characteristics and prognosis of signet-ring cell carcinoma of biliary tract[J]. 中国医药导报, 2018, 15(2): 96-99,107.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I2/96

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