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| Changes and clinical significance of serum macrophage inhibitory factor-1 levels in patients with gastric cancer before and after chemotherapy |
| XIE Yanru WU Minhua ZHOU Yuefen YE Zhongwei |
| Department of Medical Oncology, Lishui Central Hospital, Zhejiang Province, Lishui 323000, China |
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Abstract Objective To investigate the changes and the clinical significance of serum macrophage inhibitory cytokine (MIC-1) levels before and after chemotherapy in advanced gastric cancer. Methods The clinical data of 61 patients with advanced gastric cancer admitted to Lishui Central Hospital from January 2013 to January 2015 were retrospective analyzed. Double antibody sandwich ELISA method was applied to detect the serum MIC-1 levels before chemotherapy and after 2 cycles of chemotherapy. The carcinoembryonic antigen (CEA) and cancer antigen-199 (CA199) concentration in serum samples of the gastric cancer were detected by electrochemiluminescence immunoassay analyzer. Relationship between the levels of serum tumor marker before and after chemotherapy and the clinical data were analyzed. Results After chemotherapy, the levels of MIC-1, CEA and CA199 were all significantly lower than those of before chemotherapy, with statistically significant differences (P ＜ 0.05). The level of MIC-1 was correlated with the clinical stage and the degree of differentiation, with statistically significant differences (P ＜ 0.05). MIC-1 combined with CEA and CA199 as one tumor marker, before chemotherapy, the expressions were correlated with the clinical stage, the degree of differentiation and the chemotherapy efficacy (P ＜ 0.05), and was highly correlated with ascites (P ＜ 0.01). After chemotherapy, the expressions were highly correlated with ascites, differentiation and chemotherapy efficacy (P ＜ 0.01). Conclusion This study suggests that MIC-1 has high research value in the diagnosis of advanced gastric cancer. MIC-1 combine with CEA and CA199 can better evaluate the chemotherapy efficacy in patients with gastric cancer and has certain prognostic value for determining the prognosis and the occurrence. As a new tumor marker, MIC-1 has good application prospect and research value.
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