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| Systematic review and meta-analysis of Simiao Yong’an Decoction in the treatment of diabetic foot with blazing heat-toxin pattern |
| DU Yuqing1 LI Youshan1 CHEN Runming1 DONG Xueyu1 AN Qi1 LIU Yali1 ZHU Chunyan1 WANG Lu2 |
1.Department of Peripheral Vascular, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China;
2.Department of Andrology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China |
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Abstract Objective To systematically evaluate the clinical efficacy of Simiao Yong’an Decoction in the treatment of diabetic foot with heat-toxin pattern. Methods CNKI, Wanfang Data, VIP, PubMed, Embase, Web of Science and The Cochrane Library databases were searched by computer. The retrieval time was from the establishment time of database to February 15, 2020. The randomized controlled trials of Simiao Yong’an Decoction for the treatment of diabetic foot with blazing heat-toxin pattern were searched, on the basis of strict quality evaluation, the RevMan5.3 software was used for meta-analysis. Results Nineteen literatures were finally included, including 1380 patients. There were 694 cases in the treatment group and 686 cases in the control group. The results of meta-analysis showed that total effective rate (RR = 1.26, 95%CI [1.20, 1.33], P ＜ 0.000 01) in the treatment group were significantly higher than that in the control group. Ankle-brachial index (ABI) (MD = 0.09, 95%CI [0.07, 0.12], P ＜ 0.000 01), blood flow of dorsalis pedis artery (MD = 7.46, 95%CI [5.48, 9.43], P ＜ 0.000 01), motor nerve conduction velocity (MCV) (MD = 7.44, 95%CI [6.32, 8.5], P ＜ 0.000 01), sensory nerve conduction velocity (SCV) (MD = 5.05, 95%CI [4.05, 6.05], P ＜ 0.000 01) in the treatment group were significantly better than those in the control group. There were no significant differences in both whole plasma viscosity (MD = -0.06, 95%CI [-0.16, 0.03], P = 0.19) and fasting blood glucose (GLU) (MD = -0.20, 95%CI [-0.66, -0.27], P = 0.41) between the two groups. Conclusion The current evidence shows that Simiao Yong’an Decoction can effectively improve the clinical symptoms of diabetic foot, increase ABI, blood flow of dorsalis pedis artery, MCV and SCV, decrease the level of GLU. Limited by the quantity and quality of the included studies, the above conclusions need to be verified by more high-quality studies.
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