<sup>131</sup>Ⅰ联合手术治疗老年分化型甲状腺癌的效果及预后

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Abstract Objective To study the effect and prognosis of 131Iodine (¹³¹Ⅰ) combined operation for elderly differentiated thyroid cancer. Methods A total of 82 elderly patients with differentiated thyroid cancer treated in the 2nd Affiliated Hospital of Chengdu Medical College from January 2016 to October 2017 were selected for this study. All patients received total thyroidectomy or near total thyroidectomy, and neck lymph node dissection, and then treated with ¹³¹Ⅰ. The therapeutic effect, changes of thyroglobulin and thyroglobulin antibody before and after operation, adverse reactions, recurrence and survival situation were observed. Results Among 82 elderly patients with differentiated thyroid cancer, 53 cases were successfully treated after the first ¹³¹Ⅰ treatment, and 19 cases were successfully treated after the second ¹³¹Ⅰ treatment, with a total success rate of 87.80%. Six months after operation, the level of thyroglobulin and the positive rate of anti-thyroglobulin antibody were significantly lower than those before treatment, the differences were statistically significant (all P ＜ 0.05). During ¹³¹Ⅰ treatment, a few patients had short-term adverse reactions such as throat discomfort, neck swelling, abdominal discomfort, and no serious pulmonary fibrosis, bone marrow suppression, liver and kidney function damage. At the end of follow-up, four cases relapsed and three cases died. Conclusion ¹³¹Ⅰ combined with total thyroidectomy or near total thyroidectomy is safe, effective and has a good prognosis in the treatment of differentiated thyroid cancer in the elderly, which is worthy of clinical application.

Key words： Differentiated thyroid carcinoma Elderly ¹³¹Iodine Operation Efficacy Prognosis

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	LIN Feng YU Min LUO Wenyi ZHANG Bo SHI Yuhong▲

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LIN Feng YU Min LUO Wenyi ZHANG Bo SHI Yuhong▲. Effect and prognosis of ¹³¹Ⅰ combined operation in the treatment of differentiated thyroid cancer in the elderly[J]. 中国医药导报, 2021, 18(2): 102-105.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2021/V18/I2/102

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