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| Clinical effect of Siji Antiviral Decoction combined with Oseltamivir in the treatment of influenza A in children |
| LI Yukun1 ZHOU Peng2 |
1.College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Shandong Province, Ji’nan 250000, China;
2.Department of Pediatrics, the First Affiliated Hospital of Shandong University of Traditional Chinese Medicine Shandong Hospital of Traditional Chinese Medicine, Shandong Province, Ji’nan 250000, China |
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Abstract Objective To investigate the clinical effect of Siji Antiviral Decoction combined with Oseltamivir in the treatment of influenza A in children. Methods Atotal of 82 children with influenza A who admitted to the First Affiliated Hospital of Shandong University of Traditional Chinese Medicine from October 2019 to January 2020 were selected as study objects. According to the different treatment plan, they were divided into control group (treated with Oseltamivir Phosphate Granules, 40 cases) and observation group (Siji Antivirus Decoction combined with Oseltamivir Phosphate Granules treatment, 42 cases), both groups were treated for five days. The curative effect, clinical symptom improvement time and adverse reactions of two groups were compared. The changes of traditional Chinese medicine syndrome score, serum C-reactive protein (CRP), interleukin-6 (IL-6) levels in two groups were observed before and after treatment. Results The total effective rate of observation group was higher than that of control group , and the difference was statistically significant (P < 0.05). The time of fever reduction, cough disappearance and general fatigue disappearance in observation group were shorter than those of control group, and the differences were highly statistically significant (all P < 0.01). After treatment, traditional Chinese medicine syndrome score, CRP and IL-6 levels in two groups were lower than those of control group; and observation group was lower than control group, the differences were highly statistically significant(all P < 0.01). There was no difference in the incidence of adverse reactions between the two groups(P > 0.05). Conclusion Siji Antiviral Decoction combined with Oseltamivir can rapidly improve the clinical symptoms and reduce the inflammatory reaction of children with influenza A, which has significant curative effect.
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