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| Analysis of influencing factors of adverse pregnancy outcome in early-onset preeclampsia |
| HUANG Ying SUI Shuang SONG Xiaoping ZHANG Yanmei LI Xiaoying Dilihuma·Tuerxun |
| Department of Obstetrics, the People’s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Uygur Autonomous Region, Urumqi 830000, China |
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Abstract Objective To explore the related influencing factors of adverse pregnancy outcome in early-onset preeclampsia. Methods The clinical data of 161 pregnant women with early-onset preeclampsia who hospitalized and terminated their pregnancy in the People’s Hospital of Xinjiang Uygur Autonomous Region from January 2017 to December 2019. According to the adverse pregnancy outcome, they were divided into adverse pregnancy outcome group（52 cases） and non-adverse pregnancy outcome group(109 cases). The influencing factors of adverse pregnancy outcomes in two groups were analyzed. Results There were significant differences between the two groups in prepregnancy weight, prepregnancy body mass index, serum creatinine, serum uric acid, albumin, alanine aminotransferase, aspartate amino transferase, total bilirubin, neonatal weight (P ＜ 0.05). Albumin was a protective factor for adverse pregnancy outcome in patients with early-onset preeclampsia (OR < 1, P < 0.05), while prepregnancy body mass index and alanine aminotransferase were risk factors for adverse pregnancy outcome in patients with early-onset preeclampsia (OR > 1, P < 0.05). Conclusion For overweight women planning to have a pregnancy, it is necessary to strengthen dietary guidance and weight management before pregnancy, closely monitor changes in liver and kidney function, especially changes in albumin, during pregnancy, and reasonably guide treatment decisions in the course of disease, so as to reduce the occurrence of adverse pregnancy outcomes.
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[1] 苟文丽，李春芳.如何降低子痫前期发病率及危害程度[J].中国实用妇科与产科杂志，2012，28（4）：243-244.
[2] 乔宠，杨小梅，林其德.子痫前期的流行病学研究进展[J].中国计划生育和妇产科，2013，5（6）：5-8.
[3] 李冠琳，杨慧霞.子痫前期的预测与预防[J].中华妇产科杂志，2018，53（6）：425-429.
[4] 周远洋，朱军，王艳萍，等.1996~2010年全国孕产妇死亡率变化趋势[J].中华预防医学杂志，2011，45（10）：934-939.
[5] 黄宝梅，张慧萍.不典型子痫前期临床特点及高危因素分析[J].中国计划生育学杂志，2020，28（5）：771-774.
[6] 周蓓，谢恺俐.子痫前期发病机制研究进展[J].中南大学学报：医学版，2020，45（9）：1136-1141.
[7] 李银萌，严滨.子痫前期相关影响因素分析[J].大连医科大学学报，2020，42（3）：243-246.
[8] 谢幸，孔北华，段涛，等.妇产科学[M].9版.北京：人民卫生出版社，2018：83-90.
[9] von Dadelszen P，Payne B，Li J，et al. Prediction of adverse maternal outcomes in pre-eclampsia：development and validation of the fullPIERS model [J]. Lancet，2011， 377（9761）：219-227.
[10] 杨孜，张为远.妊娠期高血压疾病的早期识别（一）[J].中华妇产科杂志，2019，54（7）：501-502.
[11] 季燕雯，陈先侠，王海霞，等.早发型子痫前期不良妊娠结局的影响因素分析[J].实用医学杂志，2020，36（12）：1590-1594.
[12] 袁祎，徐巧霖，李丽洁，等.妊娠晚期血管内皮生长因子、同型半胱氨酸、血清白蛋白、血尿酸与子痫前期的相关性分析[J].心脑血管病防治，2020，20（3）：310-312.
[13] 鲁晶泉，王志梅，朱启英.孕早期体重指数及孕期增加体重对母儿不良妊娠结局的影响[J].中国实用妇科与产科杂志，2019，35（11）：1244-1247.
[14] 陈自力，杨莉莉，杨孜，等.发病前重度子痫前期患者临床预警因素分析[J].中华医学杂志，2019，99（31）：2459-2462.
[15] 倪琰琰，程蔚蔚.早发型子痫前期发病机制的研究进展[J].山东医药，2016，56（8）：101-104.
[16] 李欣，李国慧，吴晓静，等.高海拔地区妊娠高血压伴肾损害的临床特点及影响因素[J].中华肾脏病杂志，2019， 35（5）：342-350.
[17] 李莉，孙美果，杨媛媛，等.早发型重度子痫前期期待治疗的预后分析[J].安徽医科大学学报，2020，55（8）：1271-1275.
[18] 卢育民，高连第.子痫前期患者血浆D-二聚体和纤维蛋白原检测的应用探讨[J].中国妇幼保健，2020，35（14）：2570-2572.
[19] 叶青，翟桂荣，杨慧丽.外周血中炎性参数与子痫前期的相关性分析[J].临床研究，2020，28（7）：15-16.
[20] Reyes O，Bonome S. Restless Legs Syndrome and Severe Preeclampsia：A Case–Control Study [J]. J Obstet Gynaecol Can，2020，42（8）:963-970.
[21] Guy GP，Leslie K，Diaz Gomez D，et al. Implementation of routine first trimester combined screening for pre-eclampsia：a clinical effectiveness study [J]. BJOG，2020.[Epub ahead of print]
[22] Gaccioli F，Lager S，de Goffau MC，et al. Fetal inheritance of chromo-somally integrated human herpesvirus 6 predisposes the mother to pre-eclampsia [J]. Nat Microbiol，2020，5（7）:901-908.
[23] 刘兆董，赵扬玉，魏瑗，等.子痫前期双胎孕妇血小板参数及凝血功能指标变化的临床分析[J].中国生育健康杂志，2020，31（3）：210-214.
[24] 侯书宁，程文国，刘艳，等.子痫前期孕妇实验室指标水平及其对妊娠结局的影响[J].安徽医学，2020，41（4）：439-442.
[25] 罗永红，刘记.重度子痫前期并发低蛋白血症对妊娠结局的影响[J].重庆医学，2015，44（24）：3428-3431. |
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