先天性心脏病合并不同程度肺动脉高压患儿手术前后血浆脑钠肽前体的变化

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Abstract Objective To evaluate the changes of pro-brain natriuretic peptide (NT-proBNP) in children with congenital heart disease combined with different degrees of pulmonary hypertension (PAH) at different times before and after surgery. Methods A total of 60 children with congenital heart disease who were diagnosed and treated in the Affiliated Hospital of Inner Mongolia Medical University were collected from January 2015 to January 2018. According to the pulmonary artery pressure, they were divided into four groups, including 16 cases in the no PAH group, 16 cases in the mild PAH group, 14 cases in the moderate PAH group, and 14 cases in the severe PAH group. Preoperative transthoracic echocardiography was used to estimate the pulmonary artery systolic blood pressure, and the changes in plasma NT-proBNP concentrations at different times before and after the operation in children with different degrees of PAH were compared. Results The overall comparison of NT-proBNP levels before and after in the four groups was statistically significant (P ＜ 0.05). Among them, there was no significant difference in plasma NT-proBNP levels between the no-PAH group and the mild PAH group (P ＞ 0.05); the plasma NT-proBNP levels in the severe and moderate PAH groups were higher than those in the no PAH group and the mild PAH group, and the differences were statistically significant (P ＜ 0.05); the plasma NT-proBNP level in the severe PAH group was lower than that in the moderate PAH group, and the difference was statistically significant (P ＜ 0.05). The level of NT-proBNP in the mild PAH group after operation was higher than that before operation, and the difference was statistically significant (P ＜ 0.05). Conclusion In clinical studies, the plasma NT-proBNP level before and after surgery in children with congenital heart disease with left-to-right shunt gradually increases with the severity of PAH, which can be used as an indicator to evaluate the degree of PAH and help protect the health of patients, it is worth applying in practice.

Key words： Brain natriuretic peptide Congenital heart disease Pulmonary hypertension Clinical significance

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	GUO Junxiao REN Jie▲ ZHANG Yulong LIU Zhiping

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GUO Junxiao REN Jie▲ ZHANG Yulong LIU Zhiping. Changes of plasma pro-brain natriuretic peptide before and after operation in children with congenital heart disease with different degrees of pulmonary hypertension[J]. 中国医药导报, 2021, 18(2): 56-60.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2021/V18/I2/56

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