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| Reasearch progress of Zengshengping in the prevention and treatment of tumor |
| LIU Sida1 DENG Bo2 CHEN Dongmei2 JIA Liqun2 |
1.School of Clinical Medicine, Beijing University of Chinese Medicine (China-Japan Friendship Hospital), Beijing 100029, China;
2.Department of Oncology of Integrative Chinese and Western Medicine, China-Japan Friendship Hospital, Beijing 100029, China |
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Abstract Zengshengping is a pure traditional Chinese medicine preparation which was developed by Cancer Institute of Chinese Academy of Medical Sciences. It is mainly used to block the precancerous lesion of the esophagus, improve the postoperative survival time of patients with esophageal and cardiac cancer, and gradually apply in the treatment of oral leukoplakia, reverse the chronic atrophic gastritis intestinal metaplasia and reduce the recurrence rate of postoperative of giant cell tumor of bone in extremities. The anti-tumor mechanism of Zengshengping is mainly related to regulation of Notch signaling pathway, promotion of tumor cell apoptosis, and inhibition of tumor cell proliferation. The active components of the medicinal components, such asfraxinellone, dictamnine, maackiain, obacunone and matrine in Sophorae Tonkinensis Radix Et Rhizoma and Dictamni Cortex, may play the main anti-tumor activity. At present, the relevant basic research of Zengshengping is still limited to exploring its influence on the expression of relevant molecules in tumor cells, and its role in tumor microenvironment remains to be further explained. At the same time, most of the relevant clinical studies have problems such as a small number of patients and a lack of rigor in the study design, so the multi-center, large-sample randomized controlled trials need to be further carried out.
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