纳米炭在临床cN0期甲状腺乳头状微小癌预防性中央区淋巴结清扫中的应用价值

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Abstract Objective To investigate the application value of carbon nanoparticle in the prevention of central area lymph node dissection of papillary thyroid microcarcinoma (PTMC) at cN0 stage. Methods From January 2017 to June 2019, a total of 260 PTMC patients with clinical cervical lymph node metastasis negative (cN0) who admitted to Daping Hospital, Army Medical University were selected as study objects. They were divided into experimental group (133 cases) and control group (127 cases), according to whether carbon nanoparticle were used during the operation. All patients underwent hemithyroidectomy and isthmus excision, and preventive central area lymph node dissection was performed. Carbon nanoparticle was used in the experimental group and not in the control group. Lymph node detection and metastasis were compared between the two groups, and the rate of postoperative parathyroid injury and complications such as temporary hypocalcemia and permanent parathyroid hypoparathyroidism were further analyzed. Results The average number of detected lymph node and metastasis in experimental group were higher than those in the control group (P < 0.05 or P < 0.01). The rate of parathyroid mistranslation and incidence of temporary hypocalcemia in the experimental group were lower than those in control group (P < 0.01). There was no permanent hypoparathyroidism or recurrent laryngeal nerve injury in either group. Conclusion In the prevention central area lymph node dissection of cN0 PTMC patients, the application of carbon nanoparticle can improve the detection rate of positive lymph nodes, and help reduce the damage of parathyroid and the occurrence of postoperative complications.

Key words： Papillary thyroid microcarcinoma Carbon nanoparticle suspension Central area Lymph node dissection

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	HAO Shuai ZHAO Jianjie TIAN Wuguo CHEN Yi LUO Donglin

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HAO Shuai ZHAO Jianjie TIAN Wuguo CHEN Yi LUO Donglin. Application value of carbon nanoparticle in the prevention of central area lymph node dissection of papillary thyroid microcarcinoma at cN0 stage[J]. 中国医药导报, 2021, 18(2): 12-15,26.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2021/V18/I2/12

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