深海鱼油对应激性胃溃疡的抑制作用

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Abstract Objective To explore the inhibitory effect of deep-sea fish oil on stress gastric ulcer. Methods According to the random number table method, 24 SD rats were divided into control group, model group and fish oil group, with 8 rats in each group, half male and half female. Rats in fish oil group were gavaged with 0.84 mL/kg of deep-sea fish oil for 5 d consecutive, and rats in the other two groups were gavaged with 0.84 mL/kg of 0.9% sodium chloride solution for 5 d consecutive. The rats in three groups fasted for 24 h before the experiment. The rats in model group and fish oil group were treated with the shackled water immersion stress to make rat gastric ulcer model. After the end of the experiment, the stomach ulcer index (UI) was measured, and HE staining was performed to observe the damage of gastric mucosa. Meanwhile, the activity of superoxide dismutase (SOD) in serum was measured. Results UI of model group was higher than that of control group; UI of fish oil group was lower than that of model group (all P < 0.01). SOD level in model group was lower than that in control group; SOD level of fish oil group was higher than that of model group (P < 0.05 or P < 0.01). The gastric mucosa of rats in the control group was intact. Defects were found in the gastric mucosa of rats in both model group and fish oil group, but the defect occurred only in the superficial mucosa of fish oil group, and the degree of damage was less than that of model group. Conclusion Deep-sea fish oil has a certain inhibitory effect on stress gastric ulcer, this effect may be mediated by enhancing SOD activity and consequently promoting the ability to scavenge oxygen free radicals.

Key words： Deep-sea fish oil Stress gastric ulcer Ulcer index Superoxide dismutase

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	WANG Xinquan1 PANG Zexing1 WU Yizhao1 LIU Qixing1 OU Siwen1 YU Yinlin1 WANG Guifang2 XU Xiaoyang2
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WANG Xinquan1 PANG Zexing1 WU Yizhao1 LIU Qixing1 OU Siwen1 YU Yinlin1 WANG Guifang2 XU Xiaoyang2,3. Inhibitory effect of deep-sea fish oil on stress gastric ulcer[J]. 中国医药导报, 2021, 18(2): 8-11.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2021/V18/I2/8

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