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| Clinical effect of Irbesartan combined with Xinbao Pills in treating senile chronic heart failure complicated with sinus bradycardia |
| CHEN Zhenling ZHENG Yushui LI Wei LU Wei |
| Department of Cardiology, Wanbei Coal and Electricity Group General Hospital, Anhui Province, Suzhou 234000, China |
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Abstract Objective To observe the clinical efficacy of Irbesartan combined with Xinbao Pills in treating elderly patients with chronic heart failure complicated with sinus bradycardia. Methods From May 2014 to May 2017, 100 elderly patients with chronic heart failure complicated with sinus bradycardia in Wanbei Coal and Electricity Group General Hospital were selected and divided into observation group and control group by random number table, with 50 cases in each groups. On the basis of routine treatment of western medicine, the control group was treated with Irbesartan, and the observation group was treated with Irbesartan and Xinbao Pills. Before treatment and 8 weeks after treatment, the cardiac function, plasma N-terminal proBNP (NT-proBNP), H-FABP and 24 h DCG were compared between the two groups. Results After treatment, LVEDD, LVESD, LVEF, CO, Stroke volume and walking distance of 6 min in the two groups were improved, exepted for LVEDD, the improvement of cardiac function in the observation group was better than that of the control group (P < 0.05). The levels of plasma NT-proBNP and serum H-FABP in the observation group decreased compared with the control group (P < 0.05). The improvement rate of 24 h DCG clinical curative effect of the observation group and were better than those of the control group (P < 0.05). Conclusion Irbesartan combined Xinbao Pills can obviously improve patients′ cardiac function, improve heart rate and clinical symptoms.
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