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| Advanced in research of alkaline sphingomyelinase and lipid metabolism related diseases |
| LI Xin ZHANG Ping ZHANG Tao WANG Zhigang |
| College of Medical Laboratory Science and Technology, Harbin Medical University (Daqing), Heilongjiang Province, Daqing 163319, China |
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Abstract Alkaline sphingomyelinase (Alk-SMase) is the key enzyme for the hydrolysis of sphingomyelin in the digestive tract, which exists in the intestine and human bile. Decreased sphingomyelin hydrolysis and metabolic active products will cause cell proliferation, apoptosis, inflammation and ultimately leading to cancer. Lipid metabolism is an important metabolic process in humans. Alk-SMase and its metabolites can affect the metabolism of phospholipids, cholesterol and triglycerides in the intestine, leading to hepatobiliary diseases, intestinal inflammation and colon tumors. This article will focus on the relationship between Alk-SMase and lipid metabolism, and make a brief review of the research progress of Alk-SMase and lipid metabolism related diseases.
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