肝细胞核因子4α与肝细胞癌关系的研究进展

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Abstract Hepatocyte nuclear factor 4α (HNF4α) is a transcription factor that regulates the expression of specific genes in the liver, plays an important role in hepatocyte developmental and differentiation, liver lipid and cholesterol metabolism, liver drug metabolism and inhibits the formation of liver tumor. HNF4α mainly affects the formation and development of hepatocellular carcinoma (HCC) by inhibiting the proliferation of tumor cells, promoting the differentiation and apoptosis of tumor cells, reversing the processes of hepatocyte epithelial-mesenchymal transition. In this paper, the origin, distribution, structural characteristics, biological function of HNF4α and the role of HNF4α in the formation and development of HCC were reviewed in order to explore a new approach to HNF4α intervening in HCC.

Key words： Hepatocyte nuclear factor 4α Hepatocellular carcinoma Regulation Genetic engineering

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	JI Longshan SUN Xuehua ZHOU Zhenhua ZHANG Xin GAO Yueqiu LI Man

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JI Longshan SUN Xuehua ZHOU Zhenhua ZHANG Xin GAO Yueqiu LI Man. Research progress of the relationship between hepatocyte nuclear factor 4 alpha and hepatocellular carcinoma[J]. 中国医药导报, 2018, 15(2): 32-35.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I2/32

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