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| Association of genetic polymorphisms of rs3795987 locus allele in SERPINE2 gene with susceptibility to chronic obstructive pulmonary disease between the Han and the Uygur nationality in xinjiang |
| LIU Beilin ZHANG Yu WANG Liping WANG Jun ZHAO Jing WANG Haixu |
| Department of Respiratory Diseases, the Fifth Affiliated Hospital, Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi 830011, China |
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Abstract Objective To investigate the correlation between the gene polymorphism of serine protease inhibitor -2 (SERPINE2) rs3795987 site and chronic obstructive pulmonary disease (COPD) in Han and Uighur nationality in Xinjiang Uygur Autonomous Region. Methods Case-control studies were used in this study. From January to December in 2015, 88 Han and Uighur nationality COPD patients which were treated in the Department of Respiratory Diseases ofthe Fifth Affiliated Hospital of Xinjiang Medical University were separately selected as the COPD group. Meanwhile, 100 Han and Uighur nationality health people were separately selected as the control group. Genotype sequencing of SERPINE2 gene rs3795987 was performed by polymerase chain reaction, and results were analyzed statistically. Results ①There were statistically significant differences in the distribution of rs3795987 site in the patients with COPD in the Han and Uighur nationality in Xinjiang region (P < 0.05). ②There was no statistically significant difference between different genotypes of rs3795987 sites and COPD susceptibility between the Han and Uighur nationality in Xinjiang region(P > 0.05). Conclusion The gene polymorphism of SERPINE2 rs3795987 site and the occurrence of COPD in Han and Uighur nationality in Xinjiang region have no significant correlation.
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