|
|
Analysis on the effect of modified Simiao Powder on hyperuricemic nephropathy based on “state-target” strategy |
DENG Chenglong LIU Qian OUYANG Meiping HU Miaoqing ZHOU Ke |
Department of Nephrology, the Second Affiliated Hospital of Hu'nan University of Chinese Medicine, Hu’nan Province, Changsha 410005, China |
|
|
Abstract “State-target” strategy is first proposed by academician Tong Xiaolin. It realizes the organic combination of the characteristic advantage of traditional Chinese medicine “macro syndrome differentiation” and modern medicine “micro target”, providing a basis for the further development of traditional Chinese medicine syndrome differentiation theory. In the treatment of hyperuricemic nephropathy, for its “deficiency of spleen and kidney, phlegm-dampness-heat block” and “symptom targets” such as joint pain, dysuria, hematuria, edema, waist pain, frequent nocturia and foamy urine, etc. And “calibration targets” of urinary protein, high blood uric acid, high blood creatinine, hypertension, etc, we can use Simiao Powder plus Astragali Radix, Smilacis Glabrae Rhizoma, Dioscoreae Spongiosae Rhizoma for “conditioning” and “target” treatment. It can improve the symptoms of patients with hyperuricemic nephropathy in many ways.
|
|
|
|
|
[1] 何莉莎,宋攀,赵林华,等.态靶辨证——中医从宏观走向精准的历史选择[J].辽宁中医杂志,2020,47(1):1-4.
[2] 邢玉瑞.中医基础理论研究丛书 中医学概念问题研究[M].北京:中国中医药出版社,2017.
[3] 李水贤,谢莉青,董国英,等.中西医比较与中医现代化思路[J].山东中医药大学学报,2010,34(1):8-10,13.
[4] 李吉贵,刘士生.内科学[M].北京:中国协和医科大学出版社,2019.
[5] 刘丹丹,崔雯霞,胡云,等.高尿酸血症对慢性肾脏病影响的研究进展[J].中国临床研究,2020,33(1):120-123.
[6] 刘天元,何樟秀,郝丽荣.高尿酸血症与慢性肾脏病关系研究进展[J].中国血液净化,2018,17(6):416-419.
[7] 张金焕,张剑勇.中医药治疗尿酸性肾病研究进展[J].中国民族民间医药,2018,27(15):33-36.
[8] 唐宇.尿酸性肾病的证候学研究[D].长春:长春中医药大学,2020.
[9] 清·张秉成.成方便读[M].上海:科技卫生出版社,1958.
[10] 中华医学会,中华医学会杂志社,中华医学会全科医学分会,等.痛风及高尿酸血症基层诊疗指南(2019年)[J].中华全科医师杂志,2020,19(4):293-303.
[11] 傅延龄.方剂学[M].北京:人民卫生出版社,2020.
[12] 高妍,周海芳,刘朵,等.黄柏化学成分分析及其药理作用研究进展[J].亚太传统医药,2019,15(4):207-209.
[13] 樊克涛,闫海峰,代向东,等.二妙丸不同配伍比例对大鼠高尿酸血症的影响[J].天津中医药大学学报,2017, 36(1):43-48.
[14] 吴建方.薏苡仁提取物的抗炎、镇痛、镇静作用研究[J].转化医学电子杂志,2015,2(12):56-57.
[15] 庞琳蓉,李铭舜,沈秋娴,等.论四妙散治疗痛风的研究进展[J].光明中医,2015,30(2):409-411.
[16] 杨研华,尹莲,朱晓勤,等.牛膝总皂苷的制备及其保护尿酸钠致血管内皮细胞损伤的作用[J].中医药信息,2010,27(2):15-18.
[17] Cao Y,Gu C,Zhao F,et al. Therapeutic effects of Cyathula officinalis Kuan and its active fraction on acute blood stasis rat model and identification constituents by HPLC-QTOF/MS/MS [J]. Pharmacogn Mag,2017,13(52):693-701.
[18] 杨晓萍.黄芪治疗肾脏病的现代研究[J].辽宁中医杂志,2010,37(S1):332-334.
[19] 黄海艳,高建东.黄芪药理特性及在糖尿病肾病中运用研究概况[J].实用中医内科杂志,2011,25(10):80-82.
[20] 杨智,金一,沙小松,等.黄芪汤剂对阿霉素肾病模型大鼠肾组织中Smad4表达的影响[J].湖南师范大学学报:医学版,2015,12(1):11-13.
[21] 王琳琳,冯佳莉,刘俊芬,等.黄芪甲苷对高糖环境下人肾小球系膜细胞的氧化应激损伤的保护作用及机制[J].中国临床药理学杂志,2018,34(9):1085-1088.
[22] 孔锡容,张光荣.尿酸性肾病中药治疗十年研究进展[J].江西中医药,2007,38(3):71-73.
[23] 金晓敏,张晓熙,郭璐,等.基于NLRP3炎性体轴探讨土茯苓总黄酮对痛风性关节炎的作用和机制[J].中国实验方剂学杂志,2018,24(4):90-95.
[24] 黄意婷,赵艺蔓,庾雪鹰,等.基于网络药理学的土茯苓治疗痛风性肾病的作用机制研究[J].中国医药,2020, 15(7):1063-1066.
[25] 苏筠霞.中药“萆薢提取物”对尿酸性肾病保护作用的研究[D].兰州:甘肃农业大学,2014. |
|
|
|