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| Meta-analysis of the prognostic significance of neutrophil-to-lymphocyte ratio in chonic kidney disease |
| YANG Fangyu1 LIAO Juan2 HUANG Qianyi1 HAN Huajing1 DIAO Qizhi1 |
1.Department of Clinical Laboratory, Yongchuan Hospital, Chongqing Medical University, Chongqing 402160, China;
2.Department of Central Laboratory, Yongchuan Hospital, Chongqing Medical University, Chongqing 402160, China |
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Abstract Objective To systematically evaluate the effect of neutrophil-to-lymphocyte ratio (NLR) on the prognosis of chronic kidney disease (CKD). Methods CNKI, Wanfang Data, VIP, PubMed, EMbase, Web of Science and Cochrane Library were searched by computer, and the search period was from January 2000 to January 2020. The relevant studies on the relationship between NLR and the prognosis of CKD patients were collected. The Stata 14.0 statistical software was used to assess the pooled hazard ratio (HR), along with 95% confidence interval (CI) about all-cause mortality, adverse cardiovascular events and end-stage renal disease. Results This study included 19 studies with a total of 120 377 patients with CKD. All-cause mortality (HR = 1.39, 95%CI: 1.13-1.70, P = 0.002) and adverse cardiovascular events (HR = 1.25, 95%CI: 1.09-1.43, P = 0.001) of high NLR patients were higher than those of low NLR patients; there was no significant differents between two groups of the occurrence risk of end-stage renal disease (HR = 1.46, 95%CI: 0.95-2.26, P = 0.087). Conclusion High NLR is an independent risk factor for adverse cardiovascular events and all-cause motality in patients with CKD.
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[1] 汪知玉，陈孜瑾，蒋钻红，等.血液透析患者透析中低血压的发生情况及其与预后的关系[J].中华肾脏病杂志，2017，33（7）：495-503.
[2] 李春国，周飞.营养管理与慢性肾脏病的关系研究进展[J].中国实用医药，2020，15（12）：184-187.
[3] 罗佳佳，褚以德，李瑜琳.慢性肾脏病微炎症状态及其与营养不良关系的研究进展[J].山东医药，2016，56（14）：107-109.
[4] 毕秀龙，张道友.慢性肾脏病患者血清脂联素与微炎症状态相关性研究[J].辽宁医学院学报，2016，37（3）：73-75.
[5] Catabay C，Obi Y，Streja E，et al. Lymphocyte cell ratios and mortality among incident hemodialysis patients [J]. Am J Nephrol，2017，46（5）：408-416.
[6] Sato H，Takeuchi Y，Matsuda K，et al. Pre-Dialysis Neutrophil-Lymphocyte Ratio，a Novel and Strong Short-Term Predictor of All-Cause Mortality in Patients With Diabetic Nephropathy： Results From a Single-Center Study [J]. Ther Apher Dial，2017，21（4）：370-377.
[7] Tatar E，Mirili C，Isikyakar T，et al. The association of neutrophil/lymphocyte ratio and platelet/lymphocyte ratio with clinical outcomes in geriatric patients with stage 3–5 chronic kidney disease [J]. Acta Clin Belg，2016，71（4）：221-226.
[8] Ouellet G，Malhotra R，Penne EL，et al. Neutrophil-lymphocyte ratio as a novel predictor of survival in chronic hemodialysis patients [J]. Clin Nephrol，2016，85（4）：191-198.
[9] Chen IC，Yu CC，Wu YH，et al. Elevated neutrophil-to-lymphocyte ratio predicts intermediate-term outcomes in patients who have advanced chronic kidney disease with peripheral artery disease receiving percutaneous transluminal angioplasty [J]. Acta Cardiol Sin，2016，32（5）：532.
[10] Kato A，Tsuji T，Sakao Y，et al. A comparison of systemic inflammation-based prognostic scores in patients on regular hemodialysis [J]. Nephron Extra，2013，3（1）：91-100.
[11] Woziwodzka K，Dziewierz A，Pawica M，et al. Neutrophil-to-lymphocyte ratio predicts long-term all-cause mortality in patients with chronic kidney disease stage 5 [J]. Folia Med Cracov，2019，59（4）：55.
[12] Yaprak M，Turan MN，Dayanan R，et al. Platelet-to-lymphocyte ratio predicts mortality better than neutrophil-to-lymphocyte ratio in hemodialysis patients [J]. Int Urol Nephrol，2016，48（8）：1343-1348.
[13] Neuen BL，Leather N，Greenwood AM，et al. Neutrophil–lymphocyte ratio predicts cardiovascular and all-cause mortality in hemodialysis patients [J]. Ren Fail，2016，38（1）：70-76.
[14] Liu X，Huang R，Wu H，et al. Patient characteristics and risk factors of early and late death in incident peritoneal dialysis patients [J]. Sci Rep，2016，6：32359.
[15] An X，Mao HP，Wei X，et al. Elevated neutrophil to lymphocyte ratio predicts overall and cardiovascular mortality in maintenance peritoneal dialysis patients [J]. Int Urol Nephrol，2012，44（5）：1521-1528.
[16] Li H，Lu X，Xiong R，et al. High neutrophil-to-lymphocyte ratio predicts cardiovascular mortality in chronic hemodialysis patients [J]. Mediators Inflamm，2017， 2017：9327136.
[17] Xiang F，Chen R，Cao X，et al. Monocyte/lymphocyte ratio as a better predictor of cardiovascular and all‐cause mortality in hemodialysis patients： A prospective cohort study [J]. Hemodial Int，2018，22（1）：82-92.
[18] Solak Y，Yilmaz MI，Sonmez A，et al. Neutrophil to lymphocyte ratio independently predicts cardiovascular events in patients with chronic kidney disease [J]. Clin Exp Nephrol，2013，17（4）：532-540.
[19] Abe T，Kato S，Tsuruta Y，et al. Neutrophil/lymphocyte ratio as a predictor of cardiovascular events in incident dialysis patients：a Japanese prospective cohort study [J]. Clin Exp Nephrol，2015，19（4）：718-724.
[20] Altunoren O，Akkus G，Sezal DT，et al. Does neutrophyl to lymphocyte ratio really predict chronic kidney disease progression？[J]. Int Urol Nephrol，2019，51（1）：129-137.
[21] Yoshitomi R，Nakayama M，Sakoh T，et al. High neutrophil/lymphocyte ratio is associated with poor renal outcomes in Japanese patients with chronic kidney disease [J]. Ren Fail，2019，41（1）：238-243.
[22] Yuan Q，Wang J，Peng Z，et al. Neutrophil-to-lymphocyte ratio and incident end-stage renal disease in Chinese patients with chronic kidney disease： results from the Chinese Cohort Study of Chronic Kidney Disease（C-STRIDE）[J]. J Transl Med，2019，17（1）：86.
[23] Kocyigit I，Eroglu E，Unal A，et al. Role of neutrophil/lymphocyte ratio in prediction of disease progression in patients with stage-4 chronic kidney disease [J]. J Nephrol，2013，26（2）：358-365.
[24] 修贤杰，张萍，陈光.NLR比值在2型糖尿病慢性肾脏疾病中的意义[J].广东化工，2020，47（7）：120，106.
[25] 黄帅波，代现良，贺治青，等.中性粒细胞与淋巴细胞比值评估冠心病预后[J].国际心血管病杂志，2015，42（2）：71-74. |
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